NK Cell Isolation and Cytotoxicity by Radioactive Chromium Release Assay and DELFIA-EuTDA Cytotoxicity Assay.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2160-8_16
Abstract: Cytotoxicity assays are important in vitro tools to measure the lysis of desired target cells via an effector immune cell of choice. Specific lysis of the target cells can be determined by labeling the target… read more here.
Keywords: delfia eutda; release; target cells; cytotoxicity ... See more keywords
Role of Tunneling Nanotubules in the Cross-Talk Between Mesenchymal Stem Cells and Their Target Cells
Sign Up to like & getrecommendations! Published in 2019 at "Current Stem Cell Reports"
DOI: 10.1007/s40778-019-00154-1
Abstract: Purpose of ReviewThis review highlights recent advances in understanding of the role of tunneling nanotubules, with a focus on cancer: nanotubules are involved in chemoresistance, immunosuppression, and angiogenesis as well as metabolic changes in cancer… read more here.
Keywords: target cells; role; cancer; stem ... See more keywords
Trapping and proliferation of target cells on C60 fullerene nano fibres
Sign Up to like & getrecommendations! Published in 2017 at "Heliyon"
DOI: 10.1016/j.heliyon.2017.e00386
Abstract: The ratio of the surface area to the volume of materials increases in inverse proportion to their size and therefore the surface area of nanostructures and nanomaterials is extremely large compared to that of macroscopic… read more here.
Keywords: primary antibody; antibody; nano fibres; target cells ... See more keywords
Reduction of non‐specific toxicity of immunotoxin by intein mediated reconstitution on target cells
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.11.039
Abstract: &NA; Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo… read more here.
Keywords: specific toxicity; intein mediated; non specific; toxicity ... See more keywords
Modulating Aptamer Specificity with pH-Responsive DNA Bonds.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b08047
Abstract: Aptamers that recognize specific cells in a complex environment have emerged as invaluable molecular tools in bioanalysis and in the development of targeted therapeutics. The selective recognition of aptamers, however, can be compromised by the… read more here.
Keywords: modulating aptamer; binding ability; target cells; specificity ... See more keywords
Neuroscience: Putting a stamp on single cells
Sign Up to like & getrecommendations! Published in 2018 at "Nature Methods"
DOI: 10.1038/nmeth.4596
Abstract: approach in a variety of examples involving different viruses and target cells. In one example, they expressed a genetically encoded calcium indicator in single cells in the brain of a mouse and determined the cells’… read more here.
Keywords: neuroscience putting; putting stamp; stamp single; single cells ... See more keywords
Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22578-2
Abstract: Photoactivatable molecules enable ablation of malignant cells under the control of light, yet current agents can be ineffective at early stages of disease when target cells are similar to healthy surrounding tissues. In this work,… read more here.
Keywords: ablation; target cells; photoactivatable metabolic; metabolic warheads ... See more keywords
V-CARMA: A tool for the detection and modification of antigen-specific T cells
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116277119
Abstract: Significance Immunotherapy is a promising approach to treat cancers, infectious diseases, and autoimmunity by harnessing the power of immune cells, especially T cells. To improve the precision and efficacy of immunotherapy, the ability to genetically… read more here.
Keywords: mhc; specific cells; cognate; target cells ... See more keywords
Increased Cervical CD4+CCR5+ T Cells Among Kenyan Sex Working Women Using Depot Medroxyprogesterone Acetate
Sign Up to like & getrecommendations! Published in 2019 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2018.0188
Abstract: Abstract Depot medroxyprogesterone acetate (DMPA) is the most common hormonal contraceptive used by women in sub-Saharan Africa, however, it has been epidemiologically associated with HIV infections. To assess whether DMPA has an effect on the… read more here.
Keywords: target cells; hiv target; depot medroxyprogesterone; ccr5 ... See more keywords
Insulin suppresses transcriptional activity of yes-associated protein in insulin target cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-04-0205
Abstract: Yes-associated protein (YAP), the main transcriptional coactivator of the Hippo pathway, integrates multiple inputs from different signaling cascades. Evidence implicates YAP in the control of cellular nutrient and energy status, but the underlying mechanisms are… read more here.
Keywords: insulin target; insulin; activity; target ... See more keywords
Zim CHIC: A cohort study of immune changes in the female genital tract associated with initiation and use of contraceptives
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13287
Abstract: Problem Contraceptive hormones are systemically active, potent, and likely to invoke biological responses other than known fertility regulation impacts. We hypothesized that initiation of depot medroxyprogesterone acetate (DMPA) would increase genital HIV‐target‐cells and soluble immune… read more here.
Keywords: target cells; hiv target; study; initiation ... See more keywords