Design, synthesis, computational and biological evaluation of new benzodiazepines as CNS agents
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2017.08.005
Abstract: Abstract Two series of new benzodiazepines were synthesized and the target compounds (E1-10 and G1-10) were evaluated for antianxiety and skeletal muscle relaxant activity as CNS agents in albino mice. The chemical structures of the… read more here.
Keywords: new benzodiazepines; synthesis computational; cns agents; design synthesis ... See more keywords
Design, synthesis and anticonvulsant activity of new imidazolidindione and imidazole derivatives.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104020
Abstract: New imidazolidindiones and tetra-substituted imidazole derivatives were designed, synthesized, and evaluated for the anticonvulsant activity through pentylenetetrazole (PTZ)-induced seizures and maximal electroshock (MES) tests using valproate sodium and phenytoin sodium as reference drugs, respectively. Most… read more here.
Keywords: design synthesis; anticonvulsant activity; imidazole derivatives; synthesis anticonvulsant ... See more keywords
Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112360
Abstract: Herein, based on the theory of bioisosterism, a series of novel miconazole analogues containing selenium were designed, synthesized and their inhibitory effects on thirteen strains of pathogenic fungi were evaluated. It is especially encouraging that… read more here.
Keywords: containing selenium; miconazole analogues; novel miconazole; target compounds ... See more keywords
Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112991
Abstract: Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase (CYP51) are considered as the important antifungal targets, they… read more here.
Keywords: dual target; naphthylamide derivatives; target; derivatives dual ... See more keywords
Enhanced and green extraction polyphenols and furanocoumarins from Fig (Ficus carica L.) leaves using deep eutectic solvents
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.07.002
Abstract: Graphical abstract Figure. No Caption available. HighlightsDES was tailor‐made for efficiently extraction target compounds from Fig leaves.The tailor‐made DES exhibit enhanced extraction yield for target compounds than traditional solvent.The tailor‐made DES based microwave assist extraction… read more here.
Keywords: extraction; target compounds; tailor; made des ... See more keywords
New Constructed EEM Spectra Combined with N-PLS Analysis Approach as an Effective Way to Determine Multiple Target Compounds in Complex Samples
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238378
Abstract: Excitation–emission matrix (EEM) fluorescence spectroscopy has been applied to many fields. In this study, a simple method was proposed to obtain the new constructed three-dimensional (3D) EEM spectra based on the original EEM spectra. Then,… read more here.
Keywords: target compounds; new constructed; pls method; eem spectra ... See more keywords