Articles with "target difference" as a keyword



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DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

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Published in 2018 at "Trials"

DOI: 10.1186/s13063-018-2884-0

Abstract: BackgroundA key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for… read more here.

Keywords: target difference; sample size; difference; size calculation ... See more keywords
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Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop.

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Published in 2019 at "Health technology assessment"

DOI: 10.3310/hta23600

Abstract: BACKGROUND The randomised controlled trial is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to its design is a calculation of the number of participants needed (the… read more here.

Keywords: target difference; sample size; difference; trial ... See more keywords