Target Discovery for Precision Medicine Using High-Throughput Genome Engineering.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-63904-8_7
Abstract: Over the past few years, programmable RNA-guided nucleases such as the CRISPR/Cas9 system have ushered in a new era of precision genome editing in diverse model systems and in human cells. Functional screens using large… read more here.
Keywords: medicine; discovery precision; target discovery; high throughput ... See more keywords
Phage-based target discovery and its exploitation towards novel antibacterial molecules.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.08.015
Abstract: The deeply intertwined evolutionary history between bacteriophages and bacteria has endowed phages with highly specific mechanisms to hijack bacterial cell metabolism for their propagation. Here, we present a comprehensive, phage-driven strategy to reveal novel antibacterial… read more here.
Keywords: novel antibacterial; discovery exploitation; based target; phage ... See more keywords
Drug target discovery by magnetic nanoparticles coupled mass spectrometry
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2020.02.002
Abstract: Drug target discovery is the basis of drug screening. It elucidates the cause of disease and the mechanism of drug action, which is the essential of drug innovation. Target discovery performed in biological systems is… read more here.
Keywords: protein; target discovery; target; drug ... See more keywords
Target discovery of ebselen with a biotinylated probe.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04258f
Abstract: Despite numerous studies on ebselen over the past decade, its cellular targets remain obscure. Here we synthesized a biotinylated ebselen probe (biotin-ebselen) and characterized ebselen-binding proteins via an efficient activity-based protein profiling (ABPP) method, which… read more here.
Keywords: discovery ebselen; probe; target discovery; ebselen ... See more keywords
Abstract 4515: PIONEER: harnessing multi-omics data to enhance immunotherapeutic target discovery and development
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4515
Abstract: Introduction: Immunotherapeutic strategies have produced remarkable results in some malignancies. However, optimal cell surface targets in many childhood cancers remain elusive and tools for novel target discovery are limited. We developed a proteogenomic approach to… read more here.
Keywords: target discovery; development; cancer; pioneer ... See more keywords
Target discovery screens using pooled shRNA libraries and next-generation sequencing: A model workflow and analytical algorithm
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191570
Abstract: In the search for novel therapeutic targets, RNA interference screening has become a valuable tool. High-throughput technologies are now broadly accessible but their assay development from baseline remains resource-intensive and challenging. Focusing on this assay… read more here.
Keywords: analysis; target discovery; target; shrna ... See more keywords
Emerging target discovery and drug repurposing opportunities in chordoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1009193
Abstract: The development of effective and personalized treatment options for patients with rare cancers like chordoma is hampered by numerous challenges. Biomarker-guided repurposing of therapies approved in other indications remains the fastest path to redefining the… read more here.
Keywords: oncology; emerging target; chordoma; discovery drug ... See more keywords
Editorial: Drug Development and Target Discovery in Pulmonary Vascular Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00660
Abstract: Pulmonary vascular disease is a broad category of disorders threatening millions of people in the world, often leading to abnormal blood flow between the lungs and heart. Despite multiple drugs interfering with prostacyclin, endothelin, nitric… read more here.
Keywords: drug development; prostacyclin; pulmonary vascular; target discovery ... See more keywords