Sacubitril‐Valsartan in a routine community population: attention to volume status critical to achieving target dose
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DOI: 10.1002/ehf2.12547
Abstract: In the PARADIGM‐heart failure trial, sacubitril‐valsartan demonstrated a reduction in heart failure admissions and reduced all‐cause mortality in patients with heart failure with reduced ejection fraction. Although real world data have shown similar benefits regarding… read more here.
Keywords: achieving target; target dose; sacubitril valsartan; heart failure ... See more keywords
Similar clinical benefits from below‐target and target dose enalapril in patients with heart failure in the SOLVD Treatment trial
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DOI: 10.1002/ejhf.937
Abstract: To examine associations of below‐target and target dose of enalapril, an angiotensin‐converting enzyme (ACE) inhibitor, with outcomes in patients with heart failure and reduced ejection fraction (HFrEF) in the Studies of Left Ventricular Dysfunction (SOLVD)… read more here.
Keywords: target target; heart; heart failure; target dose ... See more keywords
Prognostic value of beta-blocker doses in patients with ventricular tachyarrhythmias
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DOI: 10.1007/s00380-021-02018-3
Abstract: The study investigates the prognostic significance of beta-blocker (BB) dose in patients with ventricular tachyarrhythmias. Limited data regarding the prognostic impact of BB dose in ventricular tachyarrhythmias is available. A large retrospective registry was used… read more here.
Keywords: patients ventricular; ventricular tachyarrhythmias; beta blocker; target dose ... See more keywords
Comparative Effectiveness of Dosing of Medical Therapy for Heart Failure: From the CHAMP-HF Registry.
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DOI: 10.1016/j.cardfail.2021.08.023
Abstract: BACKGROUND The comparative effectiveness of differing doses of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) on clinical and patient-reported outcomes in US clinical practice is unknown. This study sought to… read more here.
Keywords: target dosing; target; target dose; therapy ... See more keywords
Optimal doses of heart failure medication in women and men: perspective from daily clinical care
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DOI: 10.1093/ehjci/ehaa946.1030
Abstract: Heart failure (HF) guidelines recommend equal target doses for women and men. Recently, these recommendations have been challenged as research suggested that women with HF with reduced Ejection Fraction (HFrEF) may reach optimal treatment effect… read more here.
Keywords: heart; guideline recommended; women men; target ... See more keywords
Titration and Tolerability of Sacubitril/Valsartan for Patients With Heart Failure in Clinical Practice
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DOI: 10.1097/fjc.0000000000000643
Abstract: Abstract: Little is known about the dosing and tolerability of sacubitril/valsartan (LCZ696; Entresto, Quebec, Canada) in a nonclinical trial population. This study was conducted to evaluate the use and tolerability of sacubitril/valsartan in patients followed… read more here.
Keywords: sacubitril valsartan; target dose; target; tolerability sacubitril ... See more keywords