HDAC6 as privileged target in drug discovery: A perspective.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105274
Abstract: HDAC6, a class II b HDAC isoenzyme, stands unique in its structural and physiological functions. Besides histone modification, largely due to its cytoplasmic localization, HDAC6 also targets several non-histone proteins including Hsp90, α-tubulin, cortactin, HSF1,… read more here.
Keywords: privileged target; discovery perspective; target drug; hdac6 ... See more keywords
Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Steroids"
DOI: 10.1016/j.steroids.2016.12.010
Abstract: HIGHLIGHTSSynthetic approaches to the versatile mutitarget drug spironolactone have been reviewed.Aims to provide a comprehensive insight to the synthetic endeavors devoted to drug and its analogues/derivatives.It will help the synthetic chemist to design and prepare… read more here.
Keywords: analogues derivatives; drug; drug spironolactone; spironolactone ... See more keywords
Progress in Target Drug Molecules for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666191203113745
Abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disease that is widespread in the elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although there are many researches on anti-AD drugs, they… read more here.
Keywords: progress target; alzheimer disease; disease; drug molecules ... See more keywords