Multi-target drugs active against leishmaniasis: A paradigm of drug repurposing.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111660
Abstract: This mini-review focuses on leishmanicidal drugs that were sourced from small molecules previously approved for other diseases. The mechanisms of action of these molecules are herein explored, to probe the origins of their inter-species growth… read more here.
Keywords: target drugs; drug repurposing; target; drugs active ... See more keywords
What are the challenges with multi-targeted drug design for complex diseases?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2072827
Abstract: ABSTRACT Introduction Current findings on multifactorial diseases with a complex pathomechanism confirm that multi-target drugs are more efficient ways in treating them as opposed to single-target drugs. However, to design multi-target ligands, a number of… read more here.
Keywords: complex diseases; target drugs; design; drug ... See more keywords
Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200102115720
Abstract: Protein kinase inhibitors (PKIs) and histone deacetylase inhibitors (HDACIs) are two important classes of anticancer agents and have provided a variety of small molecule drugs for the treatment of various types of human cancers. However,… read more here.
Keywords: protein; target drugs; advances multi; target ... See more keywords
Recent Advances in The Rational Drug Design Based on Multi-target Ligands.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200102120652
Abstract: Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily… read more here.
Keywords: target drugs; target ligands; target; drug ... See more keywords
The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on one Stone.
Sign Up to like & getrecommendations! Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026622666220201151248
Abstract: Cardiovascular diseases (CVDs) comprise a group of diseases and disorders of the heart and blood vessels, which together are the number one cause of death worldwide, being associated with multiple genetic and modifiable risk factors,… read more here.
Keywords: target drugs; cardiovascular diseases; design multi; multi target ... See more keywords
Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2018.00206
Abstract: Tetrahydropyrazino-annelated theophylline (1,3-dimethylxanthine) derivatives have previously been shown to display increased water-solubility as compared to the parent xanthines due to their basic character. In the present study, we modified this promising scaffold by replacing the… read more here.
Keywords: target drugs; tetrahydropyrazino; tetrahydropyrazino annelated; a2a ... See more keywords
TRPV1-target drugs for the treatment of orofacial pain
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1568109
Abstract: Orofacial pain, encompassing sensory and emotional discomfort in the facial and oral regions, is a multifaceted condition that significantly impacts patients’ quality of life. This review focuses on the role of Transient Receptor Potential Vanilloid… read more here.
Keywords: target drugs; pain; drugs treatment; orofacial pain ... See more keywords
Therapeutic Options in Alzheimer’s Disease: From Classic Acetylcholinesterase Inhibitors to Multi-Target Drugs with Pleiotropic Activity
Sign Up to like & getrecommendations! Published in 2024 at "Life"
DOI: 10.3390/life14121555
Abstract: Alzheimer’s disease (AD) is a complex/multifactorial brain disorder involving hundreds of defective genes, epigenetic aberrations, cerebrovascular alterations, and environmental risk factors. The onset of the neurodegenerative process is triggered decades before the first symptoms appear,… read more here.
Keywords: alzheimer disease; disease; target drugs; acetylcholinesterase inhibitors ... See more keywords