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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111660
Abstract: This mini-review focuses on leishmanicidal drugs that were sourced from small molecules previously approved for other diseases. The mechanisms of action of these molecules are herein explored, to probe the origins of their inter-species growth…
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Keywords:
target drugs;
drug repurposing;
target;
drugs active ... See more keywords
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Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2072827
Abstract: ABSTRACT Introduction Current findings on multifactorial diseases with a complex pathomechanism confirm that multi-target drugs are more efficient ways in treating them as opposed to single-target drugs. However, to design multi-target ligands, a number of…
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Keywords:
complex diseases;
target drugs;
design;
drug ... See more keywords
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Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200102115720
Abstract: Protein kinase inhibitors (PKIs) and histone deacetylase inhibitors (HDACIs) are two important classes of anticancer agents and have provided a variety of small molecule drugs for the treatment of various types of human cancers. However,…
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Keywords:
protein;
target drugs;
advances multi;
target ... See more keywords
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Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200102120652
Abstract: Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily…
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Keywords:
target drugs;
target ligands;
target;
drug ... See more keywords
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2
Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026622666220201151248
Abstract: Cardiovascular diseases (CVDs) comprise a group of diseases and disorders of the heart and blood vessels, which together are the number one cause of death worldwide, being associated with multiple genetic and modifiable risk factors,…
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Keywords:
target drugs;
cardiovascular diseases;
design multi;
multi target ... See more keywords
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Published in 2018 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2018.00206
Abstract: Tetrahydropyrazino-annelated theophylline (1,3-dimethylxanthine) derivatives have previously been shown to display increased water-solubility as compared to the parent xanthines due to their basic character. In the present study, we modified this promising scaffold by replacing the…
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Keywords:
target drugs;
tetrahydropyrazino;
tetrahydropyrazino annelated;
a2a ... See more keywords