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   Articles with "target effects" as a keyword



A modified glycosylase base editor without predictable DNA off‐target effects

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recommendations! Published in 2024 at "FEBS Letters"

DOI: 10.1002/1873-3468.14970

Abstract: Glycosylase base editor (GBE) can induce C‐to‐G transversion in mammalian cells, showing great promise for the treatment of human genetic disorders. However, the limited efficiency of transversion and the possibility of off‐target effects caused by… read more here.

Keywords: dna target; target effects; glycosylase base; base editor ... See more keywords

CRISPR/Cas Systems in Genome Editing: Methodologies and Tools for sgRNA Design, Off‐Target Evaluation, and Strategies to Mitigate Off‐Target Effects

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recommendations! Published in 2020 at "Advanced Science"

DOI: 10.1002/advs.201902312

Abstract: Abstract Life sciences have been revolutionized by genome editing (GE) tools, including zinc finger nucleases, transcription activator‐Like effector nucleases, and CRISPR (clustered regulatory interspaced short palindromic repeats)/Cas (CRISPR‐associated) systems, which make the targeted modification of… read more here.

Keywords: genome editing; target effects; crispr cas; target ... See more keywords

High-quality reference genome of predatory mite Neoseiulus californicus McGregor (Acari: Phytoseiidae) provides insights into its biological traits and potential RNAi off-target effects.

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recommendations! Published in 2024 at "Pest management science"

DOI: 10.1002/ps.8570

Abstract: BACKGROUND Neoseiulus californicus is a predatory mite that can control various spider mites and other small arthropods. Despite its acknowledged effectiveness in the natural enemy market, a crucial knowledge gap exists in understanding the genomic… read more here.

Keywords: neoseiulus californicus; high quality; californicus; target effects ... See more keywords
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Off-target effects of base editors: what we know and how we can reduce it.

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recommendations! Published in 2021 at "Current genetics"

DOI: 10.1007/s00294-021-01211-1

Abstract: The recently discovered CRISPR-Cas9 modification, base editors (BEs), is considered as one of the most promising tools for correcting disease-causing mutations in humans, since it allows point substitutions to be edited without generating double-stranded DNA… read more here.

Keywords: target effects; effects base; genetics; base editors ... See more keywords

Off-target genome editing: A new discipline of gene science and a new class of medicine

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recommendations! Published in 2019 at "Cell Biology and Toxicology"

DOI: 10.1007/s10565-019-09475-7

Abstract: With an increasing growth of genome editing, off-target effects such as non-specific genetic modifications resulting from the designed process of genome editing become a new discipline of gene science and new class medicine. The degree… read more here.

Keywords: genome editing; medicine; target effects; edited cells ... See more keywords
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Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

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recommendations! Published in 2017 at "Environmental Science and Pollution Research"

DOI: 10.1007/s11356-017-9752-4

Abstract: The rapid spread of highly aggressive arboviruses, parasites, and bacteria along with the development of resistance in the pathogens and parasites, as well as in their arthropod vectors, represents a huge challenge in modern parasitology… read more here.

Keywords: target effects; control; control green; non target ... See more keywords

Non-target effects of Metarhizium brunneum (BIPESCO 5/F 52) in soil show that this fungus varies between being compatible with, or moderately harmful to, four predatory arthropods

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recommendations! Published in 2019 at "Biological Control"

DOI: 10.1016/j.biocontrol.2019.01.002

Abstract: Abstract Biological control with entomopathogenic fungi is a feasible option for regulation of pest insect populations. However, possible effects on beneficial arthropods must be considered. We assessed the non-target effects of the microbial biological control… read more here.

Keywords: target effects; predatory; non target; soil ... See more keywords
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Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.107689

Abstract: CRISPR genome editing is a promising tool for translational research but can cause undesired editing outcomes, both on target at the edited locus and off target at other genomic loci. Here, we investigate the occurrence… read more here.

Keywords: target effects; crispr editing; detection deleterious; target ... See more keywords
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What Are the Off-Target Effects of Plan “S” For Translational Investigators?

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recommendations! Published in 2019 at "JACC: Basic to Translational Science"

DOI: 10.1016/j.jacbts.2019.01.005

Abstract: “There are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there are some things we do not know. But there are… read more here.

Keywords: effects plan; target effects; plan translational; translational investigators ... See more keywords

Non-target effects of agri-environmental schemes on solitary bees and fungi in the United Kingdom

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recommendations! Published in 2022 at "Bulletin of Entomological Research"

DOI: 10.1017/s0007485322000414

Abstract: Abstract Agri-environmental schemes (AES) are used to enhance pollinator diversity on agricultural farms within the UK. Though the impacts of these schemes on archetypal pollinator species such as the bumblebee (Bombus) and honeybee (Apis) are… read more here.

Keywords: agri environmental; target effects; solitary bees; bee ... See more keywords

Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets

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recommendations! Published in 2017 at "ACS Omega"

DOI: 10.1021/acsomega.7b00291

Abstract: Chemical modifications of 2′-O-methyl (2′-OMe) and locked nucleic acid (LNA) of the nucleotides in the seed region (positions 2–8) of the small interfering RNA (siRNA) guide strand significantly reduced seed-matched (SM) off-target effects. The siRNA… read more here.

Keywords: target effects; seed; target; seed region ... See more keywords