Comprehensive assessment of nine target prediction web services: which should we choose for target fishing?
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad014
Abstract: Identification of potential targets for known bioactive compounds and novel synthetic analogs is of considerable significance. In silico target fishing (TF) has become an alternative strategy because of the expensive and laborious wet-lab experiments, explosive… read more here.
Keywords: comprehensive assessment; ensemble method; target fishing; prediction ... See more keywords
Identification of a Selective PDE4B Inhibitor From Bryophyllum pinnatum by Target Fishing Study and In Vitro Evaluation of Quercetin 3-O-α-L-Arabinopyranosyl-(1→2)-O-α-L-Rhamnopyranoside
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.01582
Abstract: Natural products are considered an important source of bioactive compounds especially in biodiversity-rich countries like Brazil. The identification of potential targets is crucial to the development of drugs from natural sources. In this context, in… read more here.
Keywords: bryophyllum pinnatum; quercetin arabinopyranosyl; target; pde4b ... See more keywords
Identification of the Molecular Mechanisms of Peimine in the Treatment of Cough Using Computational Target Fishing
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DOI: 10.3390/molecules25051105
Abstract: Peimine (also known as verticine) is the major bioactive and characterized compound of Fritillariae Thunbergii Bulbus, a traditional Chinese medicine that is most frequently used to relieve a cough. Nevertheless, its molecular targets and mechanisms… read more here.
Keywords: treatment cough; cough; target fishing; computational target ... See more keywords
Antiproliferative and Carbonic Anhydrase II Inhibitory Potential of Chemical Constituents from Lycium shawii and Aloe vera: Evidence from In Silico Target Fishing and In Vitro Testing
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DOI: 10.3390/ph13050094
Abstract: Lycium shawii Roem. & Schult and resin of Aloe vera (L.) BURM. F. are commonly used in Omani traditional medication against various ailments. Herein, their antiproliferative and antioxidant potential was explored. Bioassay-guided fractionation of the… read more here.
Keywords: carbonic anhydrase; lycium shawii; vera; silico target ... See more keywords