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   Articles with "target gene" as a keyword



Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202400794

Abstract: Sphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters. Herein, sphingosine kinase 2… read more here.

Keywords: activation; target gene; sphk2; nuclear translocation ... See more keywords

Prognostic relevance of miR‐137 and its liver microenvironment regulatory target gene AFM in hepatocellular carcinoma

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27855

Abstract: MiR‐137 has been identified as potential hepatocellular carcinoma (HCC) prognostic biomarkers. Highly relevant HCC prognostic biomarkers may be derived from combinations of miR‐137 with its target genes involved in the regulation of liver microenvironment. This… read more here.

Keywords: mir 137; hcc; liver microenvironment; target ... See more keywords

Target gene selection for sprayable dsRNA‐based biopesticide against Tetranychus urticae Koch (Acari: Tetranychidae)

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recommendations! Published in 2025 at "Pest Management Science"

DOI: 10.1002/ps.8675

Abstract: Because of the excessive use of synthetic chemicals, the two‐spotted spider mite, Tetranychus urticae Koch, a highly polyphagous pest, has developed comprehensive resistance to a broad spectrum of pesticides with diverse modes of action, raising… read more here.

Keywords: urticae koch; target gene; tetranychus urticae; dsrna based ... See more keywords

DiCre-Based Inducible Disruption of Leishmania Genes.

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recommendations! Published in 2019 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-9210-2_10

Abstract: Conditional gene deletion using dimerizable Cre recombinase (DiCre) is so far the best developed system for the phenotypic analysis of essential genes in Leishmania species. Here, we describe a protocol for the generation of a… read more here.

Keywords: dicre based; inducible disruption; based inducible; disruption leishmania ... See more keywords

Computational identification and characterization of microRNAs and their targets in Penaeus monodon

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recommendations! Published in 2018 at "Journal of Oceanology and Limnology"

DOI: 10.1007/s00343-018-6348-x

Abstract: Study on shrimp miRNAs was limited and just 7 mature miRNA sequences of Marsupenaeus japonicus are deposited in mirBase database. In this study, miRNAs and their target gene candidates were computationally identified from shrimp Penaeu… read more here.

Keywords: mir 4979; pmo; pmo mir; target gene ... See more keywords

In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation

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recommendations! Published in 2017 at "Cell"

DOI: 10.1016/j.cell.2017.10.025

Abstract: Current genome-editing systems generally rely on inducing DNA double-strand breaks (DSBs). This may limit their utility in clinical therapies, as unwanted mutations caused by DSBs can have deleterious effects. CRISPR/Cas9 system has recently been repurposed… read more here.

Keywords: crispr cas9; target; activation; gene activation ... See more keywords

Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.07.016

Abstract: Cell signaling networks coordinate specific patterns of protein expression in response to external cues, yet the logic by which signaling pathway activity determines the eventual abundance of target proteins is complex and poorly understood. Here,… read more here.

Keywords: tracing information; erk; target; information flow ... See more keywords

New Target Gene Screening Using Shortened and Random sgRNA Libraries in Microbial CRISPR Interference

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recommendations! Published in 2023 at "ACS Synthetic Biology"

DOI: 10.1021/acssynbio.2c00595

Abstract: CRISPR interference (CRISPRi) screening has been used for identification of target genes related to specific phenotypes using single-molecular guide RNA (sgRNA) libraries. In CRISPRi screening, the sizes of random sgRNA libraries contained with the original… read more here.

Keywords: sgrna libraries; target genes; random sgrna; target gene ... See more keywords
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UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-23597-9

Abstract: The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of Alzheimer’s disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting neurodegeneration in AD patients. To identify suppressors of tau-mediated AD, we perform a… read more here.

Keywords: degradation; overexpression; tau; tau degradation ... See more keywords

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

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recommendations! Published in 2019 at "Nature cell biology"

DOI: 10.1038/s41556-019-0433-z

Abstract: Yes-associated protein (YAP) is a transcriptional co-activator that regulates cell proliferation and survival by binding to a select set of enhancers for target gene activation. How YAP coordinates these transcriptional responses is unknown. Here, we… read more here.

Keywords: transcription; phase separation; topology; yap ... See more keywords

teiresias, a Fruitless target gene encoding an immunoglobulin-superfamily transmembrane protein, is required for neuronal feminization in Drosophila

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recommendations! Published in 2020 at "Communications Biology"

DOI: 10.1038/s42003-020-01327-z

Abstract: This study aims at identifying transcriptional targets of FruitlessBM (FruBM), which represents the major isoform of male-specific FruM transcription factors that induce neural sexual dimorphisms. A promoter of the axon-guidance factor gene robo1 carries the… read more here.

Keywords: protein; superfamily transmembrane; fruitless target; gene ... See more keywords