Prognostic relevance of miR‐137 and its liver microenvironment regulatory target gene AFM in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27855
Abstract: MiR‐137 has been identified as potential hepatocellular carcinoma (HCC) prognostic biomarkers. Highly relevant HCC prognostic biomarkers may be derived from combinations of miR‐137 with its target genes involved in the regulation of liver microenvironment. This… read more here.
Keywords: mir 137; hcc; liver microenvironment; target ... See more keywords
DiCre-Based Inducible Disruption of Leishmania Genes.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9210-2_10
Abstract: Conditional gene deletion using dimerizable Cre recombinase (DiCre) is so far the best developed system for the phenotypic analysis of essential genes in Leishmania species. Here, we describe a protocol for the generation of a… read more here.
Keywords: dicre based; inducible disruption; based inducible; disruption leishmania ... See more keywords
Computational identification and characterization of microRNAs and their targets in Penaeus monodon
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Oceanology and Limnology"
DOI: 10.1007/s00343-018-6348-x
Abstract: Study on shrimp miRNAs was limited and just 7 mature miRNA sequences of Marsupenaeus japonicus are deposited in mirBase database. In this study, miRNAs and their target gene candidates were computationally identified from shrimp Penaeu… read more here.
Keywords: mir 4979; pmo; pmo mir; target gene ... See more keywords
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.10.025
Abstract: Current genome-editing systems generally rely on inducing DNA double-strand breaks (DSBs). This may limit their utility in clinical therapies, as unwanted mutations caused by DSBs can have deleterious effects. CRISPR/Cas9 system has recently been repurposed… read more here.
Keywords: crispr cas9; target; activation; gene activation ... See more keywords
Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.07.016
Abstract: Cell signaling networks coordinate specific patterns of protein expression in response to external cues, yet the logic by which signaling pathway activity determines the eventual abundance of target proteins is complex and poorly understood. Here,… read more here.
Keywords: tracing information; erk; target; information flow ... See more keywords
New Target Gene Screening Using Shortened and Random sgRNA Libraries in Microbial CRISPR Interference
Sign Up to like & getrecommendations! Published in 2023 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00595
Abstract: CRISPR interference (CRISPRi) screening has been used for identification of target genes related to specific phenotypes using single-molecular guide RNA (sgRNA) libraries. In CRISPRi screening, the sizes of random sgRNA libraries contained with the original… read more here.
Keywords: sgrna libraries; target genes; random sgrna; target gene ... See more keywords
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23597-9
Abstract: The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of Alzheimer’s disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting neurodegeneration in AD patients. To identify suppressors of tau-mediated AD, we perform a… read more here.
Keywords: degradation; overexpression; tau; tau degradation ... See more keywords
Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0433-z
Abstract: Yes-associated protein (YAP) is a transcriptional co-activator that regulates cell proliferation and survival by binding to a select set of enhancers for target gene activation. How YAP coordinates these transcriptional responses is unknown. Here, we… read more here.
Keywords: transcription; phase separation; topology; yap ... See more keywords
teiresias, a Fruitless target gene encoding an immunoglobulin-superfamily transmembrane protein, is required for neuronal feminization in Drosophila
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01327-z
Abstract: This study aims at identifying transcriptional targets of FruitlessBM (FruBM), which represents the major isoform of male-specific FruM transcription factors that induce neural sexual dimorphisms. A promoter of the axon-guidance factor gene robo1 carries the… read more here.
Keywords: protein; superfamily transmembrane; fruitless target; gene ... See more keywords
Heterogeneous graph embedding model for predicting interactions between TF and target gene.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac148
Abstract: MOTIVATION Identifying the target genes of transcription factors (TFs) is of great significance for biomedical researches. However, using biological experiments to identify TF-target gene interactions is still time consuming, expensive and limited to small scale.… read more here.
Keywords: heterogeneous graph; target gene; model; graph embedding ... See more keywords
A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abh3635
Abstract: MYC regulates multiple gene programs, raising questions about the potential selectivity and downstream transcriptional consequences of MYC inhibitors as cancer therapeutics. Here, we examined the effect of a small-molecule MYC inhibitor, MYCi975, on the MYC/MAX… read more here.
Keywords: myc max; target gene; max cistromes; myc ... See more keywords