Synthesis and Biological Evaluation of a Library of Sulfonamide Analogs of Memantine to Target Glioblastoma.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300134
Abstract: A library of 34 lipophilic sulfonamides based upon the memantine core has been synthesized to identify potential drug candidates to cross the blood-brain barrier and target glioblastoma. The library was screened for in vitro activity… read more here.
Keywords: synthesis biological; target glioblastoma; biological evaluation; evaluation library ... See more keywords
Antibody-Based Formats to Target Glioblastoma: Overcoming Barriers to Protein Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00996
Abstract: Glioblastoma (GB) is recognized as the most aggressive form of primary brain cancer. Despite advances in treatment strategies that include surgery, radiation, and chemotherapy, the median survival time (∼15 months) of patients with GB has… read more here.
Keywords: target glioblastoma; glioblastoma overcoming; antibody based; based formats ... See more keywords
GFAPδ: A Promising Biomarker and Therapeutic Target in Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.859247
Abstract: GFAPδ, the delta isoform of the glial fibrillary acidic protein, is mainly expressed in the subventricular zone of the brain, together with other neural stem cell markers like nestin. The authors of this paper were… read more here.
Keywords: therapeutic target; target glioblastoma; glioblastoma; biomarker ... See more keywords