Kinetic Target‐Guided Synthesis of Small‐Molecule G‐Quadruplex Stabilizers
Sign Up to like & getrecommendations! Published in 2020 at "ChemistryOpen"
DOI: 10.1002/open.202000261
Abstract: Abstract The formation of a G‐quadruplex motif in the promoter region of the c‐MYC protooncogene prevents its expression. Accordingly, G‐quadruplex stabilization by a suitable ligand may be a viable approach for anticancer therapy. In our… read more here.
Keywords: target guided; guided synthesis; molecule; kinetic target ... See more keywords
Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00568
Abstract: Kinetic target-guided synthesis (KTGS) is a promising tool for the discovery of biologically active compounds. It relies on the identification of potent ligands that are covalently assembled by the biological targets themselves from a pool… read more here.
Keywords: guided synthesis; target guided; chemistry; kinetic target ... See more keywords
Going beyond Binary: Rapid Identification of Protein-Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00108
Abstract: Kinetic target-guided synthesis (KTGS) is a powerful screening approach that enables identification of small molecule modulators for biomolecules. While many KTGS variants have emerged, a majority of the examples suffer from limited throughput and a… read more here.
Keywords: ktgs; guided synthesis; kinetic target; target guided ... See more keywords
Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00064
Abstract: Myotonic dystrophy type 1 originates from d(CTG·CAG) repeats that undergo aberrant expansion during normal processing because the d(CTG) repeat forms stable hairpin structures. Bidirectional transcription of d(CTG·CAG) yields two RNA transcripts that undergo repeat-associated non-ATG… read more here.
Keywords: transcription; bidirectional transcription; target guided; repeat ... See more keywords
Cell-Based Kinetic Target-Guided Synthesis of an Enzyme Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.7b00535
Abstract: Finding a new drug candidate for a selected target is an expensive and time-consuming process. Target guided-synthesis, or in situ click chemistry, is a concept where the drug target is used to template the formation… read more here.
Keywords: guided synthesis; target guided; chemistry; target ... See more keywords
Isolation and purification of diterpenoids from the aerial parts of Isodon excisoides target-guided by UPLC-LTQ-Orbitrap-MS
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2017.1419225
Abstract: Abstract Cytotoxic diterpenoids were enriched and orientation prepared from the aerial parts of Isodon excisoides target-guided by UPLC-LTQ-Orbitrap-MS. Four diterpenoids were obtained, including a novel compound: 1α-acetoxy-7α, 14β, 20α-trihydroxy-ent-kaur-16-en-15-one (1); together with three known compounds… read more here.
Keywords: guided uplc; target guided; excisoides target; isodon excisoides ... See more keywords
A Target-Guided Telemanipulation Architecture for Assisted Grasping
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Robotics and Automation Letters"
DOI: 10.1109/lra.2022.3188436
Abstract: Teleoperation offers the possibility to combine human intelligence with robot power and endurance, making it a perfect solution for hostile-for-human environments. Nonetheless, when it concerns prolonged and repetitive operations, classical teleoperation interfaces that replicate one-to-one… read more here.
Keywords: telemanipulation architecture; operator; architecture assisted; guided telemanipulation ... See more keywords
Soft Sensor Modeling Method Based on Target-Guided Related Feature Learning and Its Application
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Instrumentation and Measurement"
DOI: 10.1109/tim.2022.3219482
Abstract: Currently, soft sensors have been extensively used in complex industrial processes. How to learn effective features from nonlinear process data is the core task of building precise soft sensors. Deep learning, a type of feature… read more here.
Keywords: feature; sensor modeling; soft sensor; target guided ... See more keywords
Target-Guided Isolation of Progenitors of 1,1,6-Trimethyl-1,2-dihydronaphthalene (TDN) from Riesling Wine by High-Performance Countercurrent Chromatography
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175378
Abstract: High-performance countercurrent chromatography (HPCCC) was used for the target-guided isolation of precursors of 1,1,6-trimethyl-1,2-dihydronaphthalene (TDN) from Riesling wine. In separated HPCCC fractions of an Amberlite® XAD®-2 extract obtained from a German Riesling, TDN-generating fractions were… read more here.
Keywords: riesling wine; countercurrent chromatography; target guided; tdn ... See more keywords