Stroke target identification guided by astrocyte transcriptome analysis
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23544
Abstract: Astrocytes support normal brain function, but may also contribute to neurodegeneration when they become reactive under pathological conditions such as stroke. However, the molecular underpinnings of this context‐dependent interplay between beneficial and detrimental properties in… read more here.
Keywords: transcriptome analysis; identification guided; target identification; guided astrocyte ... See more keywords
Target identification of a novel unsymmetrical 1,3,4‐oxadiazole derivative with antiproliferative properties
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30120
Abstract: 1,3,4‐Oxadiazole derivatives are widely used in research on antineoplastic drugs. Recently, we discovered a novel unsymmetrical 1,3,4‐oxadiazole compound with antiproliferative properties called 2j. To further investigate its possible targets and molecular mechanisms, RNA‐seq was performed… read more here.
Keywords: unsymmetrical oxadiazole; target identification; novel unsymmetrical; antiproliferative properties ... See more keywords
Target Identification of Bioactive Covalently Acting Natural Products.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2018_121
Abstract: There are countless natural products that have been isolated from microbes, plants, and other living organisms that have been shown to possess therapeutic activities such as antimicrobial, anticancer, or anti-inflammatory effects. However, developing these bioactive… read more here.
Keywords: acting natural; natural products; covalently acting; target identification ... See more keywords
Target Identification of Small Molecules Using Large-Scale CRISPR-Cas Mutagenesis Scanning of Essential Genes.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1720-5_3
Abstract: Target deconvolution of new bioactive agents identified from phenotypic screens remains a challenging task. The discovery of mutations that confer resistance to such agents is regarded as the gold standard proof of target identification. Here,… read more here.
Keywords: mutagenesis; crispr; target; essential genes ... See more keywords
Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules.
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DOI: 10.1007/978-1-4939-7201-2_6
Abstract: An important aspect for gaining functional insight into the activity of small molecules revealed through phenotypic screening is the identification of their interacting proteins. Yet, isolating and validating these interacting proteins remains difficult. Here, we… read more here.
Keywords: chloroalkane; small molecules; target identification; cell ... See more keywords
Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4176-z
Abstract: Cardiovascular disease is the major cause of morbidity and mortality in developed countries and atherosclerosis is the major cause of cardiovascular disease. Atherosclerotic lesions obstruct blood flow in the arterial vessel wall and can rupture… read more here.
Keywords: atherosclerotic plaques; identification diagnosis; target identification; vessel wall ... See more keywords
A combinatorial in silico approach for microRNA-target identification: Order out of chaos.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.05.004
Abstract: Contemporary computational microRNA(miRNA)-target prediction tools have been playing a vital role in pursuing putative targets for a solitary miRNA or a group of miRNAs. These tools utilise a set of probabilistic algorithms, machine learning techniques… read more here.
Keywords: target identification; mirna target; microrna; target ... See more keywords
Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.12.007
Abstract: Invasive fungal infections are accompanied by high mortality rates that range up to 90%. At present, only three different compound classes are available for use in the clinic, and these often suffer from low bioavailability,… read more here.
Keywords: benzamide; identification mechanism; identification; target identification ... See more keywords
Inferring individual network edges - with application to target identification in gene networks
Sign Up to like & getrecommendations! Published in 2020 at "IFAC-PapersOnLine"
DOI: 10.1016/j.ifacol.2020.12.050
Abstract: Abstract The paper considers the problem of inferring individual network edges from time-series data. This is the problem faced in target identification, but also important in cases where it is of interest to learn whether… read more here.
Keywords: inferring individual; target identification; individual network; network edges ... See more keywords
Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites
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DOI: 10.1016/j.isci.2020.101871
Abstract: Summary Boron-containing compounds represent a promising class of molecules with proven efficacy against a wide range of pathogens, including apicomplexan parasites. Following lead optimization, the benzoxaborole AN13762 was identified as a preclinical candidate against the… read more here.
Keywords: identification antimalarial; oxaborole identifies; target identification; identifies an13762 ... See more keywords
IFPTarget: A Customized Virtual Target Identification Method Based on Protein-Ligand Interaction Fingerprinting Analyses.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00225
Abstract: Small-molecule target identification is an important and challenging task for chemical biology and drug discovery. Structure-based virtual target identification has been widely used, which infers and prioritizes potential protein targets for the molecule of interest… read more here.
Keywords: protein; virtual target; method; target ... See more keywords