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Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200102120652
Abstract: Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily…
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Keywords:
target drugs;
target ligands;
target;
drug ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules28010147
Abstract: A series of new congeners, 1-[2-(1-adamantyl)ethyl]-1H-benzimidazole (AB) and 1-[2-(1-adamantyl)ethyl]-4,5,6,7-tetrahalogeno-1H-benzimidazole (Hal=Cl, Br, I; tClAB, tBrAB, tIAB), have been synthesized and studied. These novel multi-target ligands combine a benzimidazole ring known to show antitumor activity and an…
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Keywords:
molecular docking;
hirshfeld surfaces;
novel multi;
multi target ... See more keywords