Integrins as a drug target in liver fibrosis
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DOI: 10.1111/liv.15157
Abstract: As the worldwide prevalence of chronic liver diseases is high and continuing to increase, there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality. Integrins are heterodimeric cell‐surface proteins that are promising… read more here.
Keywords: liver fibrosis; target liver; drug target; fibrosis ... See more keywords
Engineered IFN-α and anti-PDL1 containing compounds to target the liver and restore antiviral protection for HBV cure
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DOI: 10.1136/gutjnl-2022-328902
Abstract: Chronic HBV infection, with hepatic inflammation and viral genome persistence in the hepatocytes either in the form of cccDNA or partially integrated into the host nucleus, is one of the major causes of liver cirrhosis… read more here.
Keywords: effect; hbv; anti pdl1; ifn ... See more keywords
MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.860661
Abstract: MicroRNAs (miRNAs) are endogenous non-coding single-stranded small molecule RNAs consisting of 20–24 nucleotides that are highly conserved in species evolution. Expression of miRNAs is strictly tissue-specific, and it is chronological in fungi and plants, as… read more here.
Keywords: therapeutic target; 223 regulator; liver; mir 223 ... See more keywords