Target-mediated exposure enhancement: a previously unexplored limit of TMDD
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DOI: 10.1007/s10928-020-09693-1
Abstract: Target-mediated drug disposition (TMDD) is often observed for targeted therapeutics, and manifests as decreases in clearance and volume of distribution with increasing dose as a result of saturable, high affinity target binding. In the present… read more here.
Keywords: previously unexplored; exposure enhancement; mediated exposure; target ... See more keywords
Target‐Mediated Drug Disposition Pharmacokinetic/Pharmacodynamic Model‐Informed Dose Selection for the First‐in‐Human Study of AVB‐S6‐500
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DOI: 10.1111/cts.12706
Abstract: AVB‐S6‐500 neutralized growth arrest‐specific 6 (GAS6) protein and effectively inhibited AXL signaling in preclinical cancer models. A target‐mediated drug disposition (TMDD) pharmacokinetic/pharmacodynamic (PK/PD) model was used to select first‐in‐human (FIH) doses for AVB‐S6‐500 based on… read more here.
Keywords: gas6 suppression; model; avb 500; target mediated ... See more keywords
Target‐mediated drug disposition modeling of an anti‐TFPI antibody (MG1113) in cynomolgus monkeys to predict human pharmacokinetics and pharmacodynamics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15244
Abstract: MG1113 is a human monoclonal antibody of tissue factor pathway inhibitor (TFPI) under development for prophylaxis for hemophilia patients with or without inhibitors against factor VIII products, which have been used for the treatment of… read more here.
Keywords: disposition modeling; antibody; mediated drug; tfpi ... See more keywords
Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody
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DOI: 10.1186/s13550-018-0358-8
Abstract: BackgroundIdeally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development. However, the imaging signal consists of specific, as… read more here.
Keywords: mediated uptake; immuno pet; antibody; anti cd44 ... See more keywords
Infliximab Efficacy May Be Linked to Full TNF-α Blockade in Peripheral Compartment—A Double Central-Peripheral Target-Mediated Drug Disposition (TMDD) Model
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DOI: 10.3390/pharmaceutics13111821
Abstract: Infliximab is an anti-TNF-α monoclonal antibody approved in chronic inflammatory bowel diseases (IBD). This study aimed at providing an in-depth description of infliximab target-mediated pharmacokinetics in 133 IBD patients treated with 5 mg/kg infliximab at… read more here.
Keywords: model; central peripheral; mediated drug; target mediated ... See more keywords