Abstract B060: Side-by-side comparison of small molecule IDO1 inhibitors in biochemical and cell-based assays and development of aIDO1-expressing mouse model to evaluate target modulation
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DOI: 10.1158/1535-7163.targ-19-b060
Abstract: Introduction: Indoleamine 2,3-dioxygenase (IDO1) is a heme-containing oxidoreductase enzyme that converts L-tryptophan (Trp) into N’-formylkynurenine (NFK). IDO1 is broadly expressed by tumor cells as well as immune cells in the tumor microenvironment of many cancers,… read more here.
Keywords: target modulation; ido1 inhibitors; model; cell ... See more keywords