Mammalian Chemical Genomics towards Identifying Targets and Elucidating Modes‐of‐Action of Bioactive Compounds
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DOI: 10.1002/cbic.202100561
Abstract: The step of identifying target molecules and elucidating the mode of action of bioactive compounds is a major bottleneck for drug discovery from phenotypic screening. Genetic screening for genes that affect drug sensitivity or phenotypes… read more here.
Keywords: chemical; action bioactive; target molecules; action ... See more keywords
General Surface-Enhanced Raman Spectroscopy Method for Actively Capturing Target Molecules in Small Gaps.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c02169
Abstract: Over the past decade, many efforts have been devoted to designing and fabricating substrates for surface-enhanced Raman spectroscopy (SERS) with abundant hot spots to improve the sensitivity of detection. However, there have been many difficulties… read more here.
Keywords: detection; method; target molecules; spectroscopy ... See more keywords
New Approaches for the Synthesis of Heterocyclic Compounds Corporating benzo[d]imidazole as Anticancer Agents, Tyrosine, Pim-1 Kinases Inhibitions and their PAINS Evaluations.
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DOI: 10.2174/1871520620666200721111230
Abstract: BACKGROUND Benzo[d]imidazoles are highly biologically active, in addition, they are considered as a class of heterocyclic compounds with many pharmaceutical applications. OBJECTIVE We are aiming in this work to synthesize target molecules not only possess… read more here.
Keywords: anticancer agents; heterocyclic compounds; benzo imidazole; target molecules ... See more keywords
Vasculitis: From Target Molecules to Novel Therapeutic Approaches
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DOI: 10.3390/biomedicines9070757
Abstract: Systemic vasculitis is a group of diverse diseases characterized by immune-mediated inflammation of blood vessels. Current treatments for vasculitis, such as glucocorticoids and alkylating agents, are associated with significant side effects. In addition, the management… read more here.
Keywords: molecules novel; vasculitis target; vasculitis; therapeutic approaches ... See more keywords
Current Trends in Molecular Imprinting: Strategies, Applications and Determination of Target Molecules in Spain
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DOI: 10.3390/ijms24031915
Abstract: Over the last decades, an increasing demand for new specific molecular recognition elements has emerged in order to improve analytical methods that have already been developed in order to reach the detection/quantification limits of target… read more here.
Keywords: target molecules; current trends; molecular imprinting; trends molecular ... See more keywords