Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS
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DOI: 10.1016/j.chembiol.2017.07.009
Abstract: Summary Mutations activating KRAS underlie many forms of cancer, but are refractory to therapeutic targeting. Here, we develop Poloppin, an inhibitor of protein-protein interactions via the Polo-box domain (PBD) of the mitotic Polo-like kinases (PLKs),… read more here.
Keywords: protein; protein interactions; mutant kras; target mutant ... See more keywords