Progranulin as a therapeutic target in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.11.015
Abstract: Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. It regulates lysosomal biogenesis, inflammation, repair, stress response, and… read more here.
Keywords: progranulin therapeutic; target neurodegenerative; pgrn; gene ... See more keywords
The case for complement component 5 as a target in neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2023.2177532
Abstract: ABSTRACT Introduction Complement-based drug discovery is undergoing a renaissance, empowered by new advances in structural biology, complement biology and drug development. Certain components of the complement pathway, particularly C1q and C3, have been extensively studied… read more here.
Keywords: disease; case complement; neurodegenerative disease; target neurodegenerative ... See more keywords