Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation.
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DOI: 10.1016/j.ejmech.2020.112451
Abstract: We report the design of hetero-bifunctional small molecules that selectively target p38α and p38β for degradation. These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38α and p38β, which is linked… read more here.
Keywords: degradation; target p38; protacs; p38 p38 ... See more keywords