Pharmacophore Identification, Virtual Screening and Activity Verification of Pedunsaponin A on Target Proteins PcAdv and PcnWAS of Pomacea canaliculata.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6936
Abstract: Target-protein-based pesticide screening has attracted wide-ranging attention on pesticide science. Pedunsaponin A (PA) is a compound isolated from the root of Pueraria peduncularis, and it has a strong toxic effect on Pomacea canaliculata. Previous studies… read more here.
Keywords: pcadv pcnwas; virtual screening; target proteins; target ... See more keywords
Interaction of S100A6 with Target Proteins In Vitro and in Living Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9030-6_23
Abstract: S100A6 is a member of the EF-hand Ca2+-binding protein family, which plays important roles in a wide variety of Ca2+ signaling in the cells, as well as in pathophysiological conditions. Herein, we describe analytical protocols… read more here.
Keywords: interaction s100a6; target proteins; target; living cells ... See more keywords
A perspective on potential target proteins of COVID-19: Comparison with SARS-CoV for designing new small molecules
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic Chemistry"
DOI: 10.1016/j.bioorg.2020.104326
Abstract: SARS-CoV-2 (COVID-19) epidemic has created an unprecedented medical and economic crisis all over the world. SARS-CoV-2 is found to have more contagious character as compared to MERS-CoV and is spreading in a very fast manner… read more here.
Keywords: small molecules; target proteins; designing new; new small ... See more keywords
Recent advances in identifying protein targets in drug discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.12.001
Abstract: Phenotype-based screening has emerged as an alternative route for discovering new chemical entities toward first-in-class therapeutics. However, clarifying their mode of action has been a significant bottleneck for drug discovery. For target protein identification, conventionally… read more here.
Keywords: drug discovery; target proteins; small molecules; target ... See more keywords
Complex network theory for the identification and assessment of candidate protein targets
Sign Up to like & getrecommendations! Published in 2018 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2018.04.015
Abstract: In this work we use complex network theory to provide a statistical model of the connectivity patterns of human proteins and their interaction partners. Our intention is to identify important proteins that may be predisposed… read more here.
Keywords: complex network; protein targets; network theory; target proteins ... See more keywords
Data-mining technique identifies potential target proteins playing a dual role in inflammation and oxidative stress pathways in relation to atherosclerosis plaque development
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2019.100278
Abstract: Abstract Cardiovascular diseases (CVDs) are the leading cause of death worldwide. An underlying source of most CVDs is atherosclerosis. The scarcity of effective drugs, and the side effects of existing marketed drugs, necessitates the discovery… read more here.
Keywords: oxidative stress; inflammation oxidative; target proteins; stress ... See more keywords
Highly Accurate and Robust Absolute Quantification of Target Proteins in Formalin-Fixed Paraffin-Embedded (FFPE) Tissues by LC-MS.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03473
Abstract: Accurate, absolute liquid chromatography-mass spectrometry (LC-MS)-based quantification of target proteins in formalin-fixed paraffin-embedded (FFPE) tissues would greatly expand sample availability for pharmaceutical/clinical investigations but remains challenging owing to the following issues: (i) efficient/quantitative recovery of… read more here.
Keywords: quantification; ffpe tissues; target proteins; quantification target ... See more keywords
Quantitative Chemoproteomic Profiling of Targets of Au(I) Complexes by Competitive Activity-Based Protein Profiling.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00080
Abstract: Owing to the encouraging pharmacological action and acceptable toxicity profile, Au(I) complexes have attracted growing interest in the application of disease treatment. In order to investigate their potential target proteins and related bioinformation, herein, we… read more here.
Keywords: competitive activity; target proteins; activity based; based protein ... See more keywords
Techniques and Strategies for Potential Protein Target Discovery and Active Pharmaceutical Molecule Screening in a Pandemic
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.0c00372
Abstract: Viruses remain a major challenge in the fierce fight against diseases. There have been many pandemics caused by various viruses throughout the world over the years. Recently, the global outbreak of COVID-19 has had a… read more here.
Keywords: strategies potential; active molecules; target proteins; target ... See more keywords
Ni2+-BSA Directional Coordination-Assisted Magnetic Molecularly Imprinted Microspheres with Enhanced Specific Rebinding to Target Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b06507
Abstract: Protein imprinting technology is of interest in drug delivery, biosensor, solid-phase extractions and so forth. However, the efficient recognition and separation of proteins have remained challenging to date. Toward that, under the assistance of Ni2+-BSA… read more here.
Keywords: ni2 bsa; directional coordination; imprinted microspheres; bsa directional ... See more keywords
Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00127
Abstract: Since ibrutinib was approved by the FDA as an effective monotherapy for chronic lymphocytic leukemia (CLL) and multilymphoma, more and more FDA-approved covalent drugs are coming back into the market. On this occasion, the resurgence… read more here.
Keywords: discovery covalent; covalent; target proteins; covalent dna ... See more keywords