Probing the phosphatidylinositol 3‐kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
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DOI: 10.1002/cncr.30909
Abstract: Activation of the phosphatidylinositol 3‐kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low‐grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. read more here.
Keywords: gliomas; mammalian target; phosphatidylinositol kinase; target rapamycin ... See more keywords
Angiotensin-Converting Enzyme Inhibitor Rapidly Ameliorates Depressive-Type Behaviors via Bradykinin-Dependent Activation of Mammalian Target of Rapamycin Complex 1
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DOI: 10.1016/j.biopsych.2020.02.005
Abstract: BACKGROUND Angiotensin-converting enzyme inhibitors (ACEIs) are widely prescribed antihypertensive agents. Intriguingly, case reports and clinical trials have indicated that ACEIs, including captopril and lisinopril, may have a rapid mood-elevating effect in certain patients, but few… read more here.
Keywords: mammalian target; converting enzyme; angiotensin converting; stress model ... See more keywords
Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In Vivo.
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DOI: 10.1016/j.transproceed.2017.04.012
Abstract: BACKGROUND The influence of immunosuppressants on hepatitis C virus (HCV) re-infection after liver transplantation, particularly mammalian target of rapamycin inhibitors, remains unclear. The aim of our study was to analyze the influence of everolimus (EVR)… read more here.
Keywords: replication activity; mammalian target; hcv replication; target rapamycin ... See more keywords
Prevalence of Cervical Infection With Human Papillomavirus of High Oncogenic Potential in Immunosuppressed Women on Renal Replacement Therapy With and Without Mammalian Target of Rapamycin Inhibitors.
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DOI: 10.1016/j.transproceed.2018.02.124
Abstract: BACKGROUND Chronic immunosuppression constitutes a risk factor of human papillomavirus (HPV) related cervical cancer development. Maintenance immunosuppression with mammalian target of rapamycin (mTOR) inhibitors is associated with decreased incidence of de novo malignancies in kidney… read more here.
Keywords: cervical infection; mtor inhibitors; mammalian target; mtor ... See more keywords
Early Switch to Mammalian Target of Rapamycin Inhibitors Is a Sustainable Treatment Approach in Renal Transplant Recipients: 7-Year Results.
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DOI: 10.1016/j.transproceed.2019.01.098
Abstract: OBJECTIVE The aim of this study was to investigate the safety and sustainability of mammalian target of rapamycin inhibitor (m-TORi)-based treatment protocols in renal transplant patients. METHODS We retrospectively evaluated a total of 206 patients… read more here.
Keywords: sustainable treatment; mammalian target; treatment; target rapamycin ... See more keywords
The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior
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DOI: 10.1038/s41398-020-01014-x
Abstract: The mammalian target of rapamycin (mTOR) is a ubiquitously expressed serine/threonine kinase protein complex (mTORC1 or mTORC2) that orchestrates diverse functions ranging from embryonic development to aging. However, its brain tissue-specific roles remain less explored.… read more here.
Keywords: haloperidol induced; rapamycin mtor; mammalian target; mtor ... See more keywords
Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status
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DOI: 10.1038/s41420-019-0219-x
Abstract: Energy sensing is indispensable to balance anabolic and catabolic processes for the maintenance of cell viability. Pancreatic β cells are especially relevant because of their involvement in the coordination of insulin secretion when glucose concentration… read more here.
Keywords: cell death; pancreatic cells; target rapamycin; mechanistic target ... See more keywords
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
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DOI: 10.1038/s41467-017-01862-0
Abstract: The target of rapamycin (TOR) kinase assembles into two distinct multiprotein complexes, conserved across eukaryote evolution. In contrast to TOR complex 1 (TORC1), TORC2 kinase activity is not inhibited by the macrolide rapamycin. Here, we… read more here.
Keywords: torc2; target rapamycin; structure; tor ... See more keywords
Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1
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DOI: 10.1038/s41598-019-53909-5
Abstract: Inactivation of the protein complex ‘mechanistic target of rapamycin complex 1’ (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transducer and activator… read more here.
Keywords: apoptosis; target rapamycin; pkc; rapamycin ... See more keywords
Anti-inflammatory Effects of Cardamonin in Ovarian Cancer Cells Are Mediated via mTOR Suppression.
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DOI: 10.1055/a-0626-7426
Abstract: Cardamonin exhibits a variety of pharmacological activities including anti-inflammatory and antitumor, which are correlated with the inhibition of nuclear factor-kappaB and the mammalian target of rapamycin, respectively. However, whether the anti-inflammatory effects of cardamonin are… read more here.
Keywords: anti inflammatory; mammalian target; target; target rapamycin ... See more keywords
Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways
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DOI: 10.1080/17512433.2020.1698288
Abstract: ABSTRACT Introduction: Dementia is the 7th leading cause of death that imposes a significant financial and service burden on the global population. Presently, only symptomatic care exists for cognitive loss, such as Alzheimer’s disease. Areas… read more here.
Keywords: cognitive loss; disease; diabetes mellitus; target rapamycin ... See more keywords