Optimization of Phosphotyrosine Peptides that Target the SH2 Domain of SOCS1 and Block Substrate Ubiquitination.
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DOI: 10.1021/acschembio.1c00884
Abstract: Suppressor of cytokine signaling 1 (SOCS1) has emerged as a potential therapeutic target in inflammatory and viral diseases. SOCS1 operates via its kinase inhibitory region, Src homology 2 (SH2) domain, and SOCS box to negatively… read more here.
Keywords: domain socs1; sh2 domain; target sh2; domain ... See more keywords