Spacer‐Complementary Single‐Stranded DNA Oligonucleotides Can Serve as Target‐Specific Inhibitors in CRISPR/Cas9 Systems
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70088
Abstract: The continuous expression of the CRISPR/Cas system in organisms can lead to various potential issues. Some anti‐CRISPR strategies have been developed to achieve precise control over CRISPR/Cas, yet these strategies are predominantly protein‐based, with the… read more here.
Keywords: stranded dna; target; crispr; target specific ... See more keywords
Discriminating promiscuous from target‐specific autoantibodies in COVID‐19
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250210
Abstract: Diverse autoantibodies were suggested to contribute to severe outcomes of COVID‐19, but their functional implications are largely unclear. ACE2, the SARS‐CoV‐2 receptor and a key regulator of blood pressure, was described to be one of… read more here.
Keywords: discriminating promiscuous; promiscuous target; target specific; autoantibodies covid ... See more keywords
Towards an Enrichment Optimization Algorithm (EOA)‐based Target Specific Docking Functions for Virtual Screening
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Informatics"
DOI: 10.1002/minf.202200034
Abstract: Docking‐based virtual screening (VS) is a common starting point in many drug discovery projects. While ligand‐based approaches may sometimes provide better results, the advantage of docking lies in its ability to provide reliable ligand binding… read more here.
Keywords: enrichment optimization; virtual screening; target specific; eoa ... See more keywords
OTUP workflow: target specific optimization of the transmit k‐space trajectory for flexible universal parallel transmit RF pulse design
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4728
Abstract: To optimize transmit k‐space trajectories for a wide range of excitation targets and to design “universal pTx RF pulses” based on these trajectories. read more here.
Keywords: otup workflow; transmit; transmit space; target specific ... See more keywords
Development of a Telerobotic Target‐Specific Pesticide Applicator: An Intervention for Enhanced Safety and Efficiency
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Field Robotics"
DOI: 10.1002/rob.22524
Abstract: Advances in computing and electronics are finding applications in agriculture. These facilitate the automation of farm operations performed manually under greenhouse structures. During chemical application, farm workers are exposed to toxic chemicals and experience fatigue… read more here.
Keywords: pesticide; specific pesticide; efficiency; application ... See more keywords
Biomarkers and Target-Specific Small-Molecule Drugs in Alzheimer’s Diagnostic and Therapeutic Research: From Amyloidosis to Tauopathy
Sign Up to like & getrecommendations! Published in 2024 at "Neurochemical Research"
DOI: 10.1007/s11064-024-04178-w
Abstract: Alzheimer’s disease (AD) is the most common type of human dementia and is responsible for over 60% of diagnosed dementia cases worldwide. Abnormal deposition of β-amyloid and the accumulation of neurofibrillary tangles have been recognised… read more here.
Keywords: diagnostic therapeutic; molecule drugs; small molecule; target specific ... See more keywords
In vivo Protein Evolution, Next Generation Protein Engineering Strategy: from Random Approach to Target-specific Approach
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-018-0394-2
Abstract: In vivo protein evolution is a protein engineering approach that is performed by both generating mutagenesis libraries and selecting desired mutants in a cell. Despite its clear advantages in some aspects, the approach has not… read more here.
Keywords: protein; target specific; vivo protein; protein evolution ... See more keywords
Thermodynamically designed target-specific DNA probe as an electrochemical hybridization biosensor.
Sign Up to like & getrecommendations! Published in 2020 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2020.107553
Abstract: Applications of molecular techniques to elucidate identity or function using biomarkers still remain highly empirical and biosensors are no exception. In the present study, target-specific oligonucleotide probes for E. coli K12 were designed thermodynamically and… read more here.
Keywords: probe; target specific; biosensor; dna ... See more keywords
The first target specific, highly diastereoselective synthesis, design and characterization of pyranoquinolinyl acrylic acid diastereomers as potential α-glucosidase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.026
Abstract: In the present investigation we report the first target specific, highly diastereoselective synthesis of new class of pyranoquinolinyl/furoquinolinyl-acrylic acid diastereomers and evaluation of their invitro α-glucosidase inhibitory activity. All the products were thoroughly characterized by… read more here.
Keywords: target specific; diastereoselective synthesis; acrylic acid; highly diastereoselective ... See more keywords
Evaluation of dabigatran, rivaroxaban and apixaban target-specific assays in a multicenter French study.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis research"
DOI: 10.1016/j.thromres.2017.09.001
Abstract: Dabigatran etexilate, rivaroxaban and apixaban (DOACs) are widely used and measurement of their concentration is desirable in certain clinical situations. Target-specific assays are available but limited information exists on their performance especially in their ability… read more here.
Keywords: multicenter; dabigatran rivaroxaban; target specific; rivaroxaban apixaban ... See more keywords
The Development of Target-Specific Machine Learning Models as Scoring Functions for Docking-Based Target Prediction
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00773
Abstract: The identification of possible targets for a known bioactive compound is of the utmost importance for drug design and development. Molecular docking is one possible approach for in-silico protein target prediction, whereas a molecule is… read more here.
Keywords: scoring functions; target specific; target; target prediction ... See more keywords