Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells
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DOI: 10.3390/cancers11091359
Abstract: The CDH1 gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric cancer and inactivating germline CDH1 mutations are responsible for hereditary diffuse gastric cancer syndrome (HDGC). Using… read more here.
Keywords: cadherin deficient; akt inhibitors; gastric cancer; target synthetic ... See more keywords