Similar clinical benefits from below‐target and target dose enalapril in patients with heart failure in the SOLVD Treatment trial
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DOI: 10.1002/ejhf.937
Abstract: To examine associations of below‐target and target dose of enalapril, an angiotensin‐converting enzyme (ACE) inhibitor, with outcomes in patients with heart failure and reduced ejection fraction (HFrEF) in the Studies of Left Ventricular Dysfunction (SOLVD)… read more here.
Keywords: target target; heart; heart failure; target dose ... See more keywords
CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
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DOI: 10.1038/s41467-022-28244-5
Abstract: CRISPR-Cas9 genome editing has potential to cure diseases without current treatments, but therapies must be safe. Here we show that CRISPR-Cas9 editing can introduce unintended mutations in vivo, which are passed on to the next… read more here.
Keywords: structural variants; target target; crispr cas9; target ... See more keywords
Upper Limb Kinematics in Stroke and Healthy Controls Using Target-to-Target Task in Virtual Reality
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DOI: 10.3389/fneur.2018.00300
Abstract: Background Kinematic analysis using virtual reality (VR) environment provides quantitative assessment of upper limb movements. This technique has rarely been used in evaluating motor function in stroke despite its availability in stroke rehabilitation. Objective To… read more here.
Keywords: target target; movement; healthy controls; target ... See more keywords
Contextual Similarity Between Successive Targets Modulates Inhibition of Return in the Target-Target Paradigm
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DOI: 10.3389/fpsyg.2020.02052
Abstract: Inhibition of return (IOR) refers to slower responses to a target presented at a previously cued vs. uncued location. The present study investigated the role of memory retrieval in IOR by manipulating the contextual similarity… read more here.
Keywords: contextual similarity; successive targets; target target; target ... See more keywords