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   Articles with "target therapy" as a keyword



C-MET as a potential target therapy toward personalized therapy in some pediatric tumors: An overview.

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recommendations! Published in 2018 at "Critical reviews in oncology/hematology"

DOI: 10.1016/j.critrevonc.2018.08.007

Abstract: Althoughpediatric tumors represent less than 1% of all new cancer diagnoses, they still rank the second in the list of disease-related morbidity and mortality in children in the US. Combining biomarker-driven targeted therapy with individualized… read more here.

Keywords: potential target; met potential; target therapy; pediatric tumors ... See more keywords

Target therapy for BRAF mutated anaplastic thyroid cancer: a clinical and molecular study.

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recommendations! Published in 2023 at "European journal of endocrinology"

DOI: 10.1093/ejendo/lvac011

Abstract: OBJECTIVES Anaplastic thyroid carcinoma (ATC) has a poor survival. The combination of Dabrafenib plus Trametinib (DT) had a significant impact in survival of BRAF p.V600E patients. However, durable responses may be compromised by resistance. We… read more here.

Keywords: braf; therapy; target therapy; anaplastic thyroid ... See more keywords

P18.17.B EFFECTIVENESS OF DABRAFENIB-TRAMETINIB AND LAROTRECTINIB IN ADULT RECURRENT GLIOBLASTOMA PATIENTS: A REAL-LIFE COHORT ANALYSIS FROM 3 ITALIAN CENTERS

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae144.333

Abstract: Although less than 5% and 1.5% of glioblastomas (GBM) exhibit the BRAFV600E mutation and NRTK fusion, respectively, these cases are significant because some of these patients (pts) may respond well to BRAF/MEK and NTRK inhibitors.… read more here.

Keywords: oncology; trametinib larotrectinib; target therapy; dabrafenib trametinib ... See more keywords

Identification of Potential Novel Target Therapy for Familial Hypertension: In Silico-based Multi-level Bioinformatic Analysis

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recommendations! Published in 2025 at "Journal of Hypertension"

DOI: 10.1097/01.hjh.0001118628.68303.cc

Abstract: bias. All three studies had moderate risks in participant selection due to lack of standardized start time. Chang et al and Doege et al reported inability to control for at least one major confounder. Conclusion:… read more here.

Keywords: therapy familial; potential novel; target therapy; novel target ... See more keywords

Neoadjuvant target therapy with ensartinib in lung adenocarcinoma with EML4-ALK fusion variant: a case report and literature review.

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recommendations! Published in 2022 at "Anti-cancer drugs"

DOI: 10.1097/cad.0000000000001432

Abstract: Although neoadjuvant target therapy has been used to treat patients with non-small-cell lung cancer (NSCLC), most of these patients have mutations in the epidermal growth factor receptor (EGFR) gene. Few patients to date have received… read more here.

Keywords: lung; target therapy; alk; neoadjuvant target ... See more keywords

Cutaneous side effects and types of dermatological reactions in metastatic melanoma patients treated by immunotherapies or targeted therapies: A retrospective single center study

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recommendations! Published in 2022 at "Dermatologic Therapy"

DOI: 10.1111/dth.15492

Abstract: Immunotherapy and target therapy have revolutionized treatment of stage III/IV melanoma. Both treatments show a favorable toxicity profile even if cutaneous adverse events (AEs) are frequent (30%–40% of cases). This is a retrospective single center… read more here.

Keywords: immunotherapy; metastatic melanoma; therapy; target therapy ... See more keywords
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Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy

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recommendations! Published in 2021 at "Ocular Oncology and Pathology"

DOI: 10.1159/000512174

Abstract: Background: Metastatic uveal melanoma (UM) has no effective treatment. To date, no publications have reported immunohistochemical evidence of estrogen receptors (ERs) in UM; however, changes in pathologic reporting for ER in breast carcinoma prompted a… read more here.

Keywords: potential target; estrogen; target; uveal melanoma ... See more keywords

Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

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recommendations! Published in 2019 at "OncoTargets and therapy"

DOI: 10.2147/ott.s192234

Abstract: Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple… read more here.

Keywords: mechanism target; uhrf1 protein; target therapy; protein ... See more keywords

A Long-Term and Large-Scale Real-World Study in Taiwan: Efficacy of Target Therapy in Stage IV Colorectal Cancer

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.808808

Abstract: This study expands the understanding of the role of target therapy in improving survival of patients with mCRC based on real-world study results. These data represent potential survival outcomes of Taiwanese patients with mCRC in… read more here.

Keywords: group months; therapy; group; study ... See more keywords

Gasdermin E: A Prospective Target for Therapy of Diseases

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.855828

Abstract: Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of… read more here.

Keywords: prospective target; gasdermin prospective; pyroptosis; gsdme ... See more keywords

Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy

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recommendations! Published in 2022 at "Antioxidants"

DOI: 10.3390/antiox11112302

Abstract: Neutrophils, the most abundant white blood cells in humans, are critical for host defense against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils can eradicate bacteria and clear debris. Among the microbicide proteins… read more here.

Keywords: neutrophil function; function target; function; myeloperoxidase regulation ... See more keywords