C-MET as a potential target therapy toward personalized therapy in some pediatric tumors: An overview.
Sign Up to like & getrecommendations! Published in 2018 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2018.08.007
Abstract: Althoughpediatric tumors represent less than 1% of all new cancer diagnoses, they still rank the second in the list of disease-related morbidity and mortality in children in the US. Combining biomarker-driven targeted therapy with individualized… read more here.
Keywords: potential target; met potential; target therapy; pediatric tumors ... See more keywords
Target therapy for BRAF mutated anaplastic thyroid cancer: a clinical and molecular study.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of endocrinology"
DOI: 10.1093/ejendo/lvac011
Abstract: OBJECTIVES Anaplastic thyroid carcinoma (ATC) has a poor survival. The combination of Dabrafenib plus Trametinib (DT) had a significant impact in survival of BRAF p.V600E patients. However, durable responses may be compromised by resistance. We… read more here.
Keywords: braf; therapy; target therapy; anaplastic thyroid ... See more keywords
Neoadjuvant target therapy with ensartinib in lung adenocarcinoma with EML4-ALK fusion variant: a case report and literature review.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer drugs"
DOI: 10.1097/cad.0000000000001432
Abstract: Although neoadjuvant target therapy has been used to treat patients with non-small-cell lung cancer (NSCLC), most of these patients have mutations in the epidermal growth factor receptor (EGFR) gene. Few patients to date have received… read more here.
Keywords: lung; target therapy; alk; neoadjuvant target ... See more keywords
Cutaneous side effects and types of dermatological reactions in metastatic melanoma patients treated by immunotherapies or targeted therapies: A retrospective single center study
Sign Up to like & getrecommendations! Published in 2022 at "Dermatologic Therapy"
DOI: 10.1111/dth.15492
Abstract: Immunotherapy and target therapy have revolutionized treatment of stage III/IV melanoma. Both treatments show a favorable toxicity profile even if cutaneous adverse events (AEs) are frequent (30%–40% of cases). This is a retrospective single center… read more here.
Keywords: immunotherapy; metastatic melanoma; therapy; target therapy ... See more keywords
Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Ocular Oncology and Pathology"
DOI: 10.1159/000512174
Abstract: Background: Metastatic uveal melanoma (UM) has no effective treatment. To date, no publications have reported immunohistochemical evidence of estrogen receptors (ERs) in UM; however, changes in pathologic reporting for ER in breast carcinoma prompted a… read more here.
Keywords: potential target; estrogen; target; uveal melanoma ... See more keywords
Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s192234
Abstract: Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple… read more here.
Keywords: mechanism target; uhrf1 protein; target therapy; protein ... See more keywords
A Long-Term and Large-Scale Real-World Study in Taiwan: Efficacy of Target Therapy in Stage IV Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.808808
Abstract: This study expands the understanding of the role of target therapy in improving survival of patients with mCRC based on real-world study results. These data represent potential survival outcomes of Taiwanese patients with mCRC in… read more here.
Keywords: group months; therapy; group; study ... See more keywords
Gasdermin E: A Prospective Target for Therapy of Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.855828
Abstract: Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of… read more here.
Keywords: prospective target; gasdermin prospective; pyroptosis; gsdme ... See more keywords
Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11112302
Abstract: Neutrophils, the most abundant white blood cells in humans, are critical for host defense against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils can eradicate bacteria and clear debris. Among the microbicide proteins… read more here.
Keywords: neutrophil function; function target; function; myeloperoxidase regulation ... See more keywords
A Soft Label Deep Learning to Assist Breast Cancer Target Therapy and Thyroid Cancer Diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215312
Abstract: Simple Summary Early diagnosis and treatment of cancer is crucial for the survival of cancer patients. Pathologists can use computational pathology techniques to make the diagnosis process more efficient and accurate. With the emergence of… read more here.
Keywords: diagnosis; breast; proposed method; cancer ... See more keywords
Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22073753
Abstract: Prostate cancer (PCa) is globally the second most diagnosed cancer type and the most common cause of cancer-related deaths in men. Family history of PCa, hereditary breast and ovarian cancer (HBOC) and Lynch syndromes (LS),… read more here.
Keywords: prostate cancer; target therapy; pca; hereditary prostate ... See more keywords