Overcoming the On‐Target Toxicity in Antibody‐Mediated Therapies via an Indirect Active Targeting Strategy
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DOI: 10.1002/advs.202206912
Abstract: Antibody‐based therapies could be led astray when target receptors are expressed on nontarget sites, and the on‐target toxicity poses critical challenges to clinical applications. Here, a biomimetic indirect active targeting (INTACT) strategy is proposed based… read more here.
Keywords: active targeting; strategy; target toxicity; indirect active ... See more keywords
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics
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DOI: 10.1126/scitranslmed.aav1386
Abstract: An in vitro multi-organ system evaluates the efficacy and potential off-target toxicities of anticancer parent drugs and metabolites. Testing for toxicity Standard methods of in vitro preclinical drug testing can be useful to detect cytotoxicity… read more here.
Keywords: system; target; drug; multi organ ... See more keywords