The kynurenine pathway; A new target for treating maternal features of preeclampsia?
Sign Up to like & getrecommendations! Published in 2019 at "Placenta"
DOI: 10.1016/j.placenta.2019.04.007
Abstract: In preeclampsia, vasospasm, oxidative stress, endothelial dysfunction, and immune dysregulation are key mediators of maternal disease. A new time-of-disease treatment is needed with the potential to treat these areas of pathophysiology. A review of the… read more here.
Keywords: treating maternal; pathway new; maternal features; kynurenine pathway ... See more keywords
KNa1.1 channels as a target for treating early-onset epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-020-00092-2
Abstract: Functions and disease associations Sodium-activated potassium channels (KNa) are opened by high concentrations of Na+ in the cytoplasm. The resulting K+ outflux counteracts the membrane potential change caused by the Na+ influx and regulates neuronal… read more here.
Keywords: epilepsy; early onset; kna1 channels; treating early ... See more keywords
Npt2a as a target for treating hyperphosphatemia
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20211005
Abstract: Hyperphosphatemia results from an imbalance in phosphate (Pi) homeostasis. In patients with and without reduced kidney function, hyperphosphatemia is associated with cardiovascular complications. The current mainstays in the management of hyperphosphatemia are oral Pi binder… read more here.
Keywords: kidney; hyperphosphatemia; npt2a target; target treating ... See more keywords
Aromatase as a target for treating endometriosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.13743
Abstract: Endometriosis is a common gynecological disease that causes various clinical symptoms, such as chronic pelvic pain, dysmenorrhea and infertility, seriously affecting women's health and their quality of life. The symptoms and endometriotic lesions are relieved,… read more here.
Keywords: aromatase target; endometriosis; estrogen; target treating ... See more keywords
AMPK: a novel target for treating hepatic fibrosis.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19376
Abstract: Fibrosis is a common process of excessive extracellular matrix (ECM) accumulation following inflammatory injury. Fibrosis is involved in the pathogenesis of almost all liver diseases for which there is no effective treatment. 5'-AMP-activated protein kinase… read more here.
Keywords: fibrosis; ampk novel; novel target; hepatic fibrosis ... See more keywords
Inflammatory response: The target for treating hyperpigmentation during the repair of a burn wound
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1009137
Abstract: Hyperpigmentation is a common complication in patients with burn injuries during wound healing; however, the mechanisms underlying its occurrence and development remain unclear. Recently, postinflammatory hyperpigmentation (PIH) was found to result from overproduction of melanin.… read more here.
Keywords: inflammatory response; response target; treating hyperpigmentation; hyperpigmentation repair ... See more keywords