AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izaa169
Abstract: BACKGROUND Fibrosis is the final common pathway to intestinal failure in Crohn's disease, but no medical therapies exist to treat intestinal fibrosis. Activated myofibroblasts are key effector cells of fibrosis in multiple organ systems, including… read more here.
Keywords: potential target; models intestinal; intestinal fibrosis; fibrosis ... See more keywords
Enkephalinases as a new pharmacological target in the treatment of gastrointestinal tract disorders
Sign Up to like & getrecommendations! Published in 2020 at "Postepy biochemii"
DOI: 10.18388/pb.2020_344
Abstract: Enkephalinases, which belong to the family of zinc metalloproteases play a crucial role in modulation of the endogenous opioid system (EOS) activity. Enkephalinase inhibitors (EI) allow obtaining therapeutic concentrations of selected endogenous peptides. One of… read more here.
Keywords: treatment gastrointestinal; treatment; new pharmacological; enkephalinases new ... See more keywords
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s350109
Abstract: Abstract Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown… read more here.
Keywords: mediated neuroinflammation; cardiovascular diseases; neuroinflammation potential; microglia mediated ... See more keywords
NF-κB as a Potential Target for the Treatment and Prevention of Mucositis.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230331121328
Abstract: Mucositis is a debilitating and severe side effect of chemotherapy and radiotherapy. It is responsible for reducing the patient's quality of life and represents a significant economic burden in oncology. Currently, there is no definitive… read more here.
Keywords: mucositis; development; target treatment; treatment ... See more keywords
NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.863774
Abstract: NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein apoptosis-associated speck-like protein containing a CARD domain, and the… read more here.
Keywords: types brain; brain; target treatment; brain injury ... See more keywords
FPR2: A Novel Promising Target for the Treatment of Influenza
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.01719
Abstract: The Formyl-peptide receptor-2 (FPR2) is a seven transmembrane G protein-coupled receptor, which plays an important role in sensing of bacteria and modulation of immune responses. FPR2 is also used by viruses for their own profit.… read more here.
Keywords: promising target; novel promising; target; target treatment ... See more keywords
CRTH2: a potential target for the treatment of organ fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022025
Abstract: Fibrosis, the self-repair process of the body after tissue damage, is a common pathological feature of many chronic inflammatory diseases. It occurs in a variety of organs, leading to structural de-struction and hypofunction, and even… read more here.
Keywords: crth2 potential; target treatment; organ fibrosis; treatment ... See more keywords