Comparison of a Target Trial Emulation Framework vs Cox Regression to Estimate the Association of Corticosteroids With COVID-19 Mortality
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.34425
Abstract: Key Points Question How do modern methods for statistical inference compare with approaches common in the clinical literature when estimating the association of corticosteroids with mortality for patients with moderate to severe COVID-19? Findings In… read more here.
Keywords: mortality; target trial; trial emulation; association corticosteroids ... See more keywords
Relevance of the antenatal corticosteroids-to-delivery interval in the prevention of neonatal respiratory distress syndrome through the eyes of causal inference: a review and target trial
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-021-06213-5
Abstract: To critically analyse the literature on the antenatal corticosteroids (ACS)-to-birth interval from a causal point of view and to present a solution to the problem of bias caused by post hoc analysis. Due to the… read more here.
Keywords: trial; target trial; acs birth; interval ... See more keywords
Target trial emulation: teaching epidemiology and beyond
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Epidemiology"
DOI: 10.1007/s10654-017-0293-4
Abstract: textabstractObservational epidemiology is continually held to thestandard of randomized trials. A typical epidemiology article references previous trials in the introduction (or reasons why trials are not feasible) and, when possible, compares the results to previous… read more here.
Keywords: target trial; epidemiology; trial; trial emulation ... See more keywords
Target Trial Emulation for Transparent and Robust Estimation of Treatment Effects for Health Technology Assessment Using Real-World Data: Opportunities and Challenges
Sign Up to like & getrecommendations! Published in 2022 at "PharmacoEconomics"
DOI: 10.1007/s40273-022-01141-x
Abstract: Evidence about the relative effects of new treatments is typically collected in randomised controlled trials (RCTs). In many instances, evidence from RCTs falls short of the needs of health technology assessment (HTA). For example, RCTs… read more here.
Keywords: target trial; world data; treatment effects; trial ... See more keywords
Target Trial Emulation and Bias Through Missing Eligibility Data: An Application to a Study of Palivizumab for the Prevention of Hospitalization Due to Infant Respiratory Illness
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwac202
Abstract: Abstract Target trial emulation (TTE) applies the principles of randomized controlled trials to the causal analysis of observational data sets. One challenge that is rarely considered in TTE is the sources of bias that may… read more here.
Keywords: eligibility; trial; target trial; eligibility data ... See more keywords
Emulating a target trial of intensive nurse home visiting in the policy-relevant population using linked administrative data
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyac092
Abstract: Abstract Background Populations willing to participate in randomized trials may not correspond well to policy-relevant target populations. Evidence of effectiveness that is complementary to randomized trials may be obtained by combining the ‘target trial’ causal… read more here.
Keywords: policy relevant; policy; target trial; population ... See more keywords
Waning of first- and second-dose ChAdOx1 and BNT162b2 COVID-19 vaccinations: a pooled target trial study of 12.9 million individuals in England, Northern Ireland, Scotland and Wales
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyac199
Abstract: Abstract Background Several SARS-CoV-2 vaccines have been shown to provide protection against COVID-19 hospitalization and death. However, some evidence suggests that notable waning in effectiveness against these outcomes occurs within months of vaccination. We undertook… read more here.
Keywords: first second; bnt162b2; covid; target trial ... See more keywords
Target trial emulation to assess real-world efficacy in the ESME metastatic breast cancer cohort.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djad092
Abstract: BACKGROUND Real-world data studies usually consider biases related to measured confounders. We emulate a target trial implementing study design principles of randomized trials to observational studies, controlling biases related to selection especially immortal time, and… read more here.
Keywords: cancer; target trial; real world; trial ... See more keywords
Effectiveness of Remdesivir Treatment Protocols Among Patients Hospitalized with COVID-19: A Target Trial Emulation
Sign Up to like & getrecommendations! Published in 2023 at "Epidemiology"
DOI: 10.1097/ede.0000000000001598
Abstract: Background: Remdesivir is recommended for certain hospitalized patients with COVID-19. However, these recommendations are based on evidence from small randomized trials, early observational studies, or expert opinion. Further investigation is needed to better inform treatment… read more here.
Keywords: remdesivir; target trial; among patients; treatment ... See more keywords
Evaluating metformin strategies for cancer prevention: a target trial emulation using electronic health records.
Sign Up to like & getrecommendations! Published in 2023 at "Epidemiology"
DOI: 10.1097/ede.0000000000001626
Abstract: BACKGROUND Metformin users appear to have a substantially lower risk of cancer than nonusers in many observational studies. These inverse associations may be explained by common flaws in observational analyses that can be avoided by… read more here.
Keywords: electronic health; target trial; metformin; cancer ... See more keywords
Effect of small vessel disease severity on blood pressure management after endovascular therapy in the BP TARGET trial
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Neurology"
DOI: 10.1111/ene.15759
Abstract: Acute ischaemic stroke patients with cerebral small vessel disease (CSVD), including cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs), have worse outcomes. The effect was investigated of two blood pressure strategies (intensive vs. standard) and… read more here.
Keywords: vessel disease; small vessel; target trial; blood ... See more keywords