Electronic medical records can be used to emulate target trials of sustained treatment strategies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2017.11.021
Abstract: OBJECTIVE To emulate three target trials: single treatment vs. no treatment, joint treatment vs. no treatment, and head-to-head comparison of two treatments, we explain how to estimate the observational analogs of intention-to-treat and per-protocol effects,… read more here.
Keywords: per protocol; treatment; target trials; electronic medical ... See more keywords
Prenatal exposure to benzodiazepine and z-hypnotics and fifth-grade scholastic skills—emulating target trials using data from the Norwegian Mother, Father and Child Cohort Study
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwae159
Abstract: Abstract Evidence is limited regarding the effect of prenatal benzodiazepine and z-hypnotic exposure and long-term neurodevelopment in childhood. The objective of this study was to investigate the effects of initiating benzodiazepine or z-hypnotic treatment in… read more here.
Keywords: data norwegian; scholastic skills; fifth grade; emulating target ... See more keywords
Emulating target trials of postexposure vaccines using observational data.
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DOI: 10.1093/aje/kwae350
Abstract: Postexposure vaccination has the potential to prevent or modify the course of clinical disease among those exposed to a pathogen. However, due to logistical constraints, postexposure vaccine trials have been difficult to implement in practice.… read more here.
Keywords: postexposure vaccines; observational data; vaccination; using observational ... See more keywords
Emulating Target Trials to Avoid Immortal Time Bias – An Application to Antibiotic Initiation and Preterm Delivery
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DOI: 10.1097/ede.0000000000001601
Abstract: Background: Randomized trials in pregnancy are extremely challenging, and observational studies are often the only option to evaluate medication safety during pregnancy. However, such studies are often susceptible to immortal time bias if treatment initiation… read more here.
Keywords: target trials; time; immortal time; time bias ... See more keywords