Electronic medical records can be used to emulate target trials of sustained treatment strategies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2017.11.021
Abstract: OBJECTIVE To emulate three target trials: single treatment vs. no treatment, joint treatment vs. no treatment, and head-to-head comparison of two treatments, we explain how to estimate the observational analogs of intention-to-treat and per-protocol effects,… read more here.
Keywords: per protocol; treatment; target trials; electronic medical ... See more keywords
Emulating Target Trials to Avoid Immortal Time Bias – An Application to Antibiotic Initiation and Preterm Delivery
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DOI: 10.1097/ede.0000000000001601
Abstract: Background: Randomized trials in pregnancy are extremely challenging, and observational studies are often the only option to evaluate medication safety during pregnancy. However, such studies are often susceptible to immortal time bias if treatment initiation… read more here.
Keywords: target trials; time; immortal time; time bias ... See more keywords