Frontline Therapy of AML in the Fit and Younger Population—Incorporating Molecularly Targeted Agents
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Hematology"
DOI: 10.1002/ajh.27585
Abstract: Backbone therapy for acute myeloid leukemia for younger adults has for 50 years been based on a combination of cytarabine and anthracycline. Over the past 10 years the addition of several targeted agents has been found to… read more here.
Keywords: fit younger; therapy; aml fit; frontline therapy ... See more keywords
Targeted agents in patients with progressive glioblastoma—A systematic meta‐analysis of randomized clinical trials
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DOI: 10.1002/cam4.7362
Abstract: Glioblastoma (GB) is the most common malignant primary brain tumor in adults and is associated with a poor prognosis. Current treatment guidelines outline the standard of care for patients with newly diagnosed GB; however, there… read more here.
Keywords: targeted agents; meta analysis; patients progressive; systematic meta ... See more keywords
Determinants of the recommended phase 2 dose of molecular targeted agents
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DOI: 10.1002/cncr.30579
Abstract: The recommended phase 2 dose (RP2D) of anticancer agents is determined traditionally by dose‐limiting toxicities. Nontoxicity or biological endpoints such as pharmacokinetics, pharmacodynamics, and efficacy can also be used to identify RP2D, which may be… read more here.
Keywords: targeted agents; phase dose; determinants recommended; recommended phase ... See more keywords
Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and Mitocans.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_37
Abstract: Mitochondria, the powerhouse of the cell, have been known for many years for their central role in the energy metabolism; however, extensive progress has been made and to date substantial evidence demonstrates that mitochondria play… read more here.
Keywords: mitochondria targeted; agents mitochondriotropics; mitochondriotropics mitochondriotoxics; mitochondriotoxics mitocans ... See more keywords
Treatment of Richter’s Transformation with Novel Therapies
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DOI: 10.1007/s11899-023-00721-8
Abstract: Purpose of Review This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter’s transformation (RT). Recent Findings Recently, numerous approaches have been investigated for the treatment of RT including:… read more here.
Keywords: treatment richter; treatment; richter transformation; targeted agents ... See more keywords
Targeted Agents in Cervical Cancer: Beyond Bevacizumab
Sign Up to like & getrecommendations! Published in 2018 at "Current Oncology Reports"
DOI: 10.1007/s11912-018-0680-3
Abstract: Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two thirds of the patients are diagnosed with locally advanced cervical cancer, showing disappointing survival rates despite correct… read more here.
Keywords: bevacizumab; targeted agents; cervical cancer; agents cervical ... See more keywords
Proportional odds assumption for modeling longitudinal ordinal multiple toxicity outcomes in dose finding studies of targeted agents: A pooled analysis of 54 studies
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2020.100529
Abstract: Background Data generated by phase I trials is richer than the classical binary DLT measured at the first cycle used as primary endpoints. Several works developed designs for more informative endpoints, e.g. ordinal toxicity grades… read more here.
Keywords: proportional odds; odds assumption; assumption; assumption modeling ... See more keywords
Efficacy of nab-paclitaxel in treating metastatic melanoma
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DOI: 10.1080/14656566.2019.1569628
Abstract: ABSTRACT Introduction: Systemic treatment of metastatic melanoma has been revolutionized by the advent of checkpoint inhibitors and targeted agents which are widely accepted as standard front-line therapies. However, despite these major advances, a substantial portion… read more here.
Keywords: melanoma; nab paclitaxel; checkpoint inhibitors; metastatic melanoma ... See more keywords
Balancing efficacy and toxicity of targeted agents currently used for the treatment of patients with chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2018.1495557
Abstract: ABSTRACT Introduction: In recent years, innovative mechanism-based drugs have enriched the therapeutic armamentarium for patients with chronic lymphocytic leukemia (CLL) and are widely used in the clinical practice. These small molecules targeting the B-cell receptor… read more here.
Keywords: lymphocytic leukemia; treatment; patients chronic; chronic lymphocytic ... See more keywords
Abstract B113: Novel thiosemicarbazones demonstrate pronounced anti-tumor activity in marginal zone lymphoma models, also overcoming resistance to targeted agents
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-b113
Abstract: Despite significant advancements in anti-lymphoma therapies in recent years, treatment failure and disease relapse remain significant clinical challenges in B-cell lymphoma. Therefore, novel therapeutic approaches with distinct mechanisms of action are essential to overcoming drug… read more here.
Keywords: resistance; novel thiosemicarbazones; resistance targeted; lymphoma ... See more keywords
Efficacy of Targeted Agents and Immune Checkpoint Inhibitors in Patients with Malignant Histiocytosis
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DOI: 10.1182/blood-2024-204398
Abstract: Introduction Malignant histiocytoses (MH), encompassing histiocytic sarcoma (HS), interdigitating dendritic cell sarcoma (IDCS), and Langerhans cell sarcoma (LCS), are a group of rare, hematologic neoplasms with diverse clinical presentations and poor outcomes. There are no… read more here.
Keywords: immune checkpoint; agents immune; targeted agents; checkpoint inhibitors ... See more keywords