Determinants of the recommended phase 2 dose of molecular targeted agents
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30579
Abstract: The recommended phase 2 dose (RP2D) of anticancer agents is determined traditionally by dose‐limiting toxicities. Nontoxicity or biological endpoints such as pharmacokinetics, pharmacodynamics, and efficacy can also be used to identify RP2D, which may be… read more here.
Keywords: targeted agents; phase dose; determinants recommended; recommended phase ... See more keywords
Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and Mitocans.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_37
Abstract: Mitochondria, the powerhouse of the cell, have been known for many years for their central role in the energy metabolism; however, extensive progress has been made and to date substantial evidence demonstrates that mitochondria play… read more here.
Keywords: mitochondria targeted; agents mitochondriotropics; mitochondriotropics mitochondriotoxics; mitochondriotoxics mitocans ... See more keywords
Targeted Agents in Cervical Cancer: Beyond Bevacizumab
Sign Up to like & getrecommendations! Published in 2018 at "Current Oncology Reports"
DOI: 10.1007/s11912-018-0680-3
Abstract: Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two thirds of the patients are diagnosed with locally advanced cervical cancer, showing disappointing survival rates despite correct… read more here.
Keywords: bevacizumab; targeted agents; cervical cancer; agents cervical ... See more keywords
Proportional odds assumption for modeling longitudinal ordinal multiple toxicity outcomes in dose finding studies of targeted agents: A pooled analysis of 54 studies
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DOI: 10.1016/j.conctc.2020.100529
Abstract: Background Data generated by phase I trials is richer than the classical binary DLT measured at the first cycle used as primary endpoints. Several works developed designs for more informative endpoints, e.g. ordinal toxicity grades… read more here.
Keywords: proportional odds; odds assumption; assumption; assumption modeling ... See more keywords
Efficacy of nab-paclitaxel in treating metastatic melanoma
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DOI: 10.1080/14656566.2019.1569628
Abstract: ABSTRACT Introduction: Systemic treatment of metastatic melanoma has been revolutionized by the advent of checkpoint inhibitors and targeted agents which are widely accepted as standard front-line therapies. However, despite these major advances, a substantial portion… read more here.
Keywords: melanoma; nab paclitaxel; checkpoint inhibitors; metastatic melanoma ... See more keywords
Balancing efficacy and toxicity of targeted agents currently used for the treatment of patients with chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2018.1495557
Abstract: ABSTRACT Introduction: In recent years, innovative mechanism-based drugs have enriched the therapeutic armamentarium for patients with chronic lymphocytic leukemia (CLL) and are widely used in the clinical practice. These small molecules targeting the B-cell receptor… read more here.
Keywords: lymphocytic leukemia; treatment; patients chronic; chronic lymphocytic ... See more keywords
Copanlisib synergizes with conventional and targeted agents including venetoclax in B- and T-cell lymphoma models.
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DOI: 10.1182/bloodadvances.2019000844
Abstract: Copanlisib is a pan-class I phosphoinositide 3-kinase (PI3K) inhibitor with preferred activity toward PI3Kα and PI3Kδ. Despite the clear overall clinical benefit, the number of patients achieving complete remissions with the single agent is relatively… read more here.
Keywords: combination; venetoclax; targeted agents; cell ... See more keywords
Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment
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DOI: 10.1186/s12885-018-4712-z
Abstract: BackgroundThe irinotecan-induced phosphokinome changes in colorectal cancer (CRC) cells were used to guide the selection of targeted agents to be tested in combination with irinotecan.MethodsPhosphokinome profiling with peptide arrays of tumour samples from nude mice… read more here.
Keywords: combination; targeted agents; rational development; treatment ... See more keywords
The role of targeted agents in the adjuvant treatment of colon cancer: a meta-analysis of randomized phase III studies and review
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DOI: 10.18632/oncotarget.16091
Abstract: There has been debate as to whether targeted agents have beneficial effect when added to adjuvant chemotherapy for patient with colon cancer. We conducted this meta-analysis to investigate the role of targeted agents in the… read more here.
Keywords: targeted agents; analysis; treatment; colon cancer ... See more keywords
Efficacy and safety of different molecular targeted agents based on chemotherapy for gastric cancer patients treatment: a network meta-analysis
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DOI: 10.18632/oncotarget.17192
Abstract: Increasing numbers of reports have been published to demonstrate that molecular targeted agents are able to improve the efficacy of chemotherapy in gastric cancer. This network meta-analysis aimed to evaluate the efficacy and safety of… read more here.
Keywords: gastric cancer; safety; molecular targeted; efficacy ... See more keywords
A network meta-analysis on the efficacy of targeted agents in combination with chemotherapy for treatment of advanced/metastatic triple-negative breast cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19102
Abstract: OBJECTIVE Our network meta-analysis aimed to determine the assistant efficacy of targeted therapy in combined with chemotherapy for advanced/metastatic triple-negative breast cancer (TNBC). RESULTS A total of 15 randomized controlled trials (RCTs), involving 2,410 patients,… read more here.
Keywords: chemotherapy; advanced metastatic; targeted agents; network meta ... See more keywords