Targeted Alpha Therapy, an Emerging Class of Cancer Agents: A Review
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.4044
Abstract: Importance Targeted alpha therapy attempts to deliver systemic radiation selectively to cancer cells while minimizing systemic toxic effects and may lead to additional treatment options for many cancer types. Observations Theoretically, the high-energy emission of… read more here.
Keywords: cancer; treatment; targeted alpha; alpha therapy ... See more keywords
Application of a new spectral deconvolution method for in vitro dosimetry in assessment of targeted alpha therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Medical physics"
DOI: 10.1002/mp.16279
Abstract: BACKGROUND The improvement of in vitro assessment of targeted alpha therapy (reproducibility, comparability of experiments…) requires precise evaluation of the dose delivered to the cells. To answer this need, a previous study proposed an innovative… read more here.
Keywords: alpha therapy; deconvolution; targeted alpha; deconvolution method ... See more keywords
Safety and efficacy of targeted alpha therapy with 213Bi-DOTA-substance P in recurrent glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4225-7
Abstract: Treatment options for recurrent glioblastoma multiforme (GBM) are very limited. GBM cells express high levels of the GPCR neurokinin type 1 receptor (NK-1R), and a modified substance P can be used as its ligand for… read more here.
Keywords: therapy; dota substance; dota; targeted alpha ... See more keywords
Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations
Sign Up to like & getrecommendations! Published in 2018 at "Targeted Oncology"
DOI: 10.1007/s11523-018-0550-9
Abstract: Alpha-emitters are radionuclides that decay through the emission of high linear energy transfer α-particles and possess favorable pharmacologic profiles for cancer treatment. When coupled with monoclonal antibodies, peptides, small molecules, or nanoparticles, the excellent cytotoxic… read more here.
Keywords: emitters targeted; alpha therapy; targeted alpha; therapy ... See more keywords
Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-018-1317-1
Abstract: Radium-223 dichloride (Ra-223) is the first targeted alpha therapy approved for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastasis. Ra-223 improved overall survival in the international Phase III ALSYMPCA (ALpharadin in… read more here.
Keywords: 223 clinical; radium 223; japan; targeted alpha ... See more keywords
Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-021-01619-2
Abstract: We present the guideline for use of [211At] sodium astatide (NaAt) for targeted alpha therapy in clinical trials on the basis of radiation safety issues in Japan. This guideline was prepared by a study supported… read more here.
Keywords: medicine; alpha therapy; 211at naat; clinical trials ... See more keywords
Biodistribution and Multi-Compartment Pharmacokinetic Analysis of a Targeted Alpha Particle Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00640
Abstract: Targeted alpha particle therapy (TAT) is ideal for treating disease while minimizing damage to surrounding non-targeted tissues due to short path-length and high linear energy transfer (LET). We developed a TAT for metastatic uveal melanoma,… read more here.
Keywords: multi compartment; particle therapy; alpha particle; compartment pharmacokinetic ... See more keywords
Elucidating the coordination chemistry of the radium ion for targeted alpha therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03156f
Abstract: The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for 223Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our… read more here.
Keywords: chemistry; coordination chemistry; alpha therapy; targeted alpha ... See more keywords
Ion-Exchange Kinetics of Alpha-Zirconium Phosphate Nanoplatelets for Application in Targeted Alpha Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Solvent Extraction and Ion Exchange"
DOI: 10.1080/07366299.2020.1780699
Abstract: ABSTRACT The loading and kinetics of uptake for the inorganic ion-exchange material, α-zirconium phosphate, Zr(HPO4)2•H2O, were investigated with ions relevant to targeted alpha therapy including natural Cs+ (as a surrogate for 221Fr), natural Bi3+ (as… read more here.
Keywords: alpha therapy; ion exchange; zirconium phosphate; targeted alpha ... See more keywords
PO-110 Targeted alpha-therapy for gastric cancer metastasized to liver in mice
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.635
Abstract: Introduction Gastric cancer often metastasizes to liver in its advanced stage. Liver metastasis of gastric cancer (LMGC) is a fetal medical condition and the patients with LMGC have extremely poor prognosis because of the lack… read more here.
Keywords: gastric cancer; trastuzumab; 211 trastuzumab; targeted alpha ... See more keywords
Revisiting the Radiobiology of Targeted Alpha Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.692436
Abstract: Targeted alpha therapy (TAT) using alpha particle-emitting radionuclides is in the spotlight after the approval of 223RaCl2 for patients with metastatic castration-resistant prostate cancer and the development of several alpha emitter-based radiopharmaceuticals. It is acknowledged… read more here.
Keywords: alpha therapy; radiobiology targeted; radiobiology; targeted alpha ... See more keywords