Self-assembled Viral Nanoparticles as Targeted Anticancer Vehicles
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-020-0383-0
Abstract: Viral nanoparticles (VNPs) comprise a variety of mammalian viruses, plant viruses, and bacteriophages, that have been adopted as building blocks and supra-molecular templates in nanotechnology. VNPs demonstrate the dynamic, monodisperse, polyvalent, and symmetrical architectures which… read more here.
Keywords: nanoparticles targeted; assembled viral; self assembled; viral nanoparticles ... See more keywords
Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.05.008
Abstract: The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a significant… read more here.
Keywords: degradation; anticancer therapies; resistance targeted; resistance ... See more keywords
Chemical strategies to overcome resistance against targeted anticancer therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-020-0596-8
Abstract: Emergence of resistance is a major factor limiting the efficacy of molecularly targeted anticancer drugs. Understanding the specific mutations, or other genetic or cellular changes, that confer drug resistance can help in the development of… read more here.
Keywords: overcome resistance; chemical strategies; resistance; strategies overcome ... See more keywords
Therapeutic Drug Monitoring of Targeted Anticancer Protein Kinase Inhibitors in Routine Clinical Use: A Critical Review.
Sign Up to like & getrecommendations! Published in 2019 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000699
Abstract: PURPOSE Therapeutic response to oral targeted anticancer protein kinase inhibitors (PKIs) varies widely between patients, with insufficient efficacy of some of them and unacceptable adverse reactions of others. There are several possible causes for this… read more here.
Keywords: drug; therapeutic drug; targeted anticancer; drug monitoring ... See more keywords
Importance of pharmacologic considerations in the development of targeted anticancer agents for children
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000001208
Abstract: Purpose of review The purpose of this review is to describe key pharmacologic considerations to inform strategies in drug development for pediatric cancer. Recent findings Main themes that will be discussed include considering patient specific… read more here.
Keywords: development; development targeted; importance pharmacologic; targeted anticancer ... See more keywords
Precision dosing of targeted anticancer drugs—challenges in the real world
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/16980
Abstract: Abstract: The prerequisites for the successful implementation of therapeutic drug monitoring (TDM) include high inter-subject variation, low inter-occasion variation, narrow therapeutic index and a strong link between plasma drug concentrations and clinical effects. The degree… read more here.
Keywords: real world; precision dosing; anticancer drugs; precision ... See more keywords
Involvement of Transporters in Intestinal Drug–Drug Interactions of Oral Targeted Anticancer Drugs Assessed by Changes in Drug Absorption Time
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112493
Abstract: (1) Background: Oral targeted anticancer drugs are victims of presystemic pharmacokinetic drug–drug interactions (DDI). Identification of the nature of these DDIs, i.e., enzyme-based or/and transporter-based, is challenging, since most of these drugs are substrates of… read more here.
Keywords: anticancer drugs; methodology; targeted anticancer; drug ... See more keywords
Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15061643
Abstract: Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative types of cytotoxic payloads is… read more here.
Keywords: cationic nanoparticles; targeted anticancer; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords