Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents
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DOI: 10.3389/fchem.2022.866392
Abstract: The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and develop novel antibacterial drugs. Two-component system (TCS), which is comprised of… read more here.
Keywords: targeted antimicrobial; kinase targeted; kinase; histidine kinase ... See more keywords
Regulatory Mechanisms of Autophagy-Targeted Antimicrobial Therapeutics Against Mycobacterial Infection
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DOI: 10.3389/fcimb.2021.633360
Abstract: Mycobacterium tuberculosis (Mtb) is an intracellular pathogen causing human tuberculosis, an infectious disease that still remains as a global health problem. Autophagy, a lysosomal degradative process, has emerged as a critical pathway to restrict intracellular… read more here.
Keywords: mechanisms autophagy; regulatory mechanisms; infection; antimicrobial therapeutics ... See more keywords
Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome
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DOI: 10.3389/fmicb.2022.879207
Abstract: The gut microbiome plays a pivotal role in maintaining the health of the hosts; however, there is accumulating evidence that certain bacteria in the host, termed pathobionts, play roles in the progression of diseases. Although… read more here.
Keywords: potential tools; targeted antimicrobial; tools modulating; gut microbiome ... See more keywords