Protective effect of mitochondrially targeted antioxidant MitoQ on oxidatively stressed fibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Papers"
DOI: 10.1007/s11696-017-0359-5
Abstract: Abstract3T3 and VH10 cells were subjected to oxidative damage by hydroxyl radicals generated from Cu(II) ions and ascorbate. The presence of reactive oxygen and nitrogen species in cells was determined using fluorescent dyes. MitoQ—a mitochondrially… read more here.
Keywords: effect mitochondrially; mitochondrially targeted; protective effect; antioxidant mitoq ... See more keywords
Effects of freezing extender supplementation with mitochondria-targeted antioxidant Mito-TEMPO on frozen-thawed rooster semen quality and reproductive performance.
Sign Up to like & getrecommendations! Published in 2020 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2020.106671
Abstract: Rooster semen cryopreservation is a useful method to utilize semen samples for artificial insemination in commercial flocks, but with use of the freezing-thawing process there is a reduction in the quality and fertilization capacity of… read more here.
Keywords: mitochondria targeted; rooster semen; mito; mito tempo ... See more keywords
Mito‐TEMPO, a mitochondria‐targeted antioxidant, prevents N‐nitrosodiethylamine‐induced hepatocarcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2019.03.037
Abstract: Background: Oxidative stress and mitochondrial dysfunction play a significant role in hepatocarcinogenesis. Mitochondria are source organelle as well as target for free radicals. The oxidative damage to mitochondria can be prevented by mitochondria‐targeted antioxidant, mito‐TEMPO.… read more here.
Keywords: mitochondria targeted; mito tempo; hepatocarcinogenesis; targeted antioxidant ... See more keywords
Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111391
Abstract: Muscle mass is important for health. Decreased testicular androgen production (hypogonadism) contributes to the loss of muscle mass, with loss of limb muscle being particularly debilitating. Androgen replacement is the only treatment, which may not… read more here.
Keywords: mitochondria targeted; muscle; limb muscle; muscle mass ... See more keywords
Mitochondria-targeted antioxidant protects against irradiation-induced salivary gland hypofunction
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86927-3
Abstract: A severe consequence of radiation therapy in patients with head and neck cancer is persistent salivary gland hypofunction which causes xerostomia and oral infections. We previously showed that irradiation (IR) of salivary glands in mice… read more here.
Keywords: irradiation; salivary gland; gland hypofunction; gland ... See more keywords
Mitochondria-targeted antioxidant SkQ1 suppresses fibrosarcoma and rhabdomyosarcoma tumour cell growth
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1496748
Abstract: ABSTRACT Mitochondria are important regulators of tumour growth and progression due to their specific role in cancer metabolism and modulation of apoptotic pathways. In this paper we describe that mitochondria-targeted antioxidant SkQ1 designed as a… read more here.
Keywords: mitochondria targeted; cell; antioxidant skq1; growth ... See more keywords
Effect of mitochondria-targeted antioxidant on the regulation of the mitochondrial function of sperm during cryopreservation.
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14431
Abstract: Sperm mitochondrion is one of the major susceptible organelles that get damaged during cryopreservation. The study aimed to minimize mitochondrial dysfunction and oxidative stress during sperm cryopreservation using mitochondria-specific antioxidants. For this, semen was collected… read more here.
Keywords: mitochondrial function; sperm cryopreservation; cryopreservation; mitochondria targeted ... See more keywords
Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gq signaling
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732356
Abstract: Generalized cellular ‘stress’ (i.e., oxidative, mitochondrial) within the syncytiotrophoblast (STB) layer of placenta is theorized to drive the pathogenesis of preeclampsia (PE), but the causes and consequences of this stress have yet to be clearly… read more here.
Keywords: cre; targeted antioxidant; specific signaling; physiology ... See more keywords
Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/9281519
Abstract: Dry eye syndrome (DES) is an age-related condition increasingly detected in younger people of risk groups, including patients who underwent ocular surgery or long-term general anesthesia. Being a multifactorial disease, it is characterized by oxidative… read more here.
Keywords: mitochondria targeted; anesthesia induced; eye syndrome; skq1 ... See more keywords
Abstract 485: Mito-Targeted Antioxidant Superior to Non-Targeted Isoform in Modulating Energy Metabolism and Preventing Cardiovascular Remodelling in Spontaneously Hypertensive Rat
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.485
Abstract: Hypertension induced left ventricular hypertrophy (LVH) augments the risk of cardiovascular anomalies. Oxidative stress leads to the activation of the hypertrophic program with a metabolic switch from fatty acid to glucose oxidation. Mitochondria, the major… read more here.
Keywords: metabolism; mito targeted; energy metabolism; targeted antioxidant ... See more keywords
Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans: A study protocol
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.980783
Abstract: Background: Cardiovascular disease (CVD) is the leading cause of death worldwide and aging is the primary risk factor for the development of CVD. The increased risk of CVD with aging is largely mediated by the… read more here.
Keywords: supplementation; vascular dysfunction; age; targeted antioxidant ... See more keywords