Genomic and Targeted Approaches Unveil the Cell Membrane as a Major Target of the Antifungal Cytotoxin Amantelide A
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202000685
Abstract: Amantelide A, a polyhydroxylated macrolide isolated from a marine cyanobacterium, displays broadâspectrum activity against mammalian cells, bacterial pathogens, and marine fungi. We conducted comprehensive mechanistic studies to identify the molecular targets and pathways affected by… read more here.
Keywords: approaches unveil; targeted approaches; unveil cell; cell ... See more keywords
Therapeutic targeted approaches for Covid-19 treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201023666220304163903
Abstract: Covid-19is declared as pandemic by WHO and non-availability of specific drug or vaccine has resulted in infection outburst and transmission. Exigent situation has rendered the repurposed drugs as effective first line of treatment against SARS-CoV-2… read more here.
Keywords: approaches covid; covid treatment; role; targeted approaches ... See more keywords
TME-targeted approaches of brain metastases and its clinical therapeutic evidence
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1131874
Abstract: The tumor microenvironment (TME), which includes both cellular and non-cellular elements, is now recognized as one of the major regulators of the development of primary tumors, the metastasis of which occurs to specific organs, and… read more here.
Keywords: brain metastases; targeted approaches; brain; tme targeted ... See more keywords