Real-world Use of and Spending on New Oral Targeted Cancer Drugs in the US, 2011-2018.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2021.5983
Abstract: Importance Launch prices of new cancer drugs in the US have substantially increased in recent years despite growing concerns about the quantity and quality of evidence supporting their approval by the US Food and Drug… read more here.
Keywords: cancer drugs; 2011 2018; targeted cancer; cancer ... See more keywords
Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204335
Abstract: With the rapid growth of advanced nanoengineering strategies, there are great implications for therapeutic immunostimulators formulated in nanomaterials to combat cancer. It is crucial to direct immunostimulators to the right tissue and specific immune cells… read more here.
Keywords: targeted cancer; clinical translation; immune cells; cancer ... See more keywords
Initial and supplementary indication approval of new targeted cancer drugs by the FDA, EMA, Health Canada, and TGA
Sign Up to like & getrecommendations! Published in 2022 at "Investigational New Drugs"
DOI: 10.1007/s10637-022-01227-5
Abstract: Background. Previous research focused on the clinical evidence supporting new cancer drugs’ initial US Food and Drug Administration (FDA) approval. However, targeted drugs are increasingly approved for supplementary indications of unknown evidence and benefit. Objectives.… read more here.
Keywords: cancer drugs; targeted cancer; approval; indication ... See more keywords
Towards targeted cancer therapy: Aptamer or oncolytic virus?
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.08.061
Abstract: &NA; Cancer is a leading cause of global mortality. Whilst anticancer awareness programs have increased significantly over the years, scientific research into the development of efficient and specific drugs to target cancerous cells for enhanced… read more here.
Keywords: towards targeted; targeted cancer; cancer; targeting elements ... See more keywords
Preparation of Sialic Acid-Imprinted Fluorescent Conjugated Nanoparticles and Their Application for Targeted Cancer Cell Imaging.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.6b14320
Abstract: Fluorescent conjugated polymer nanoparticles have attracted great interest for applications in biological imaging owing to their excellent optical properties and low cytotoxicity; however, a lack of effective targeting limits their use. In this work, we… read more here.
Keywords: polymer nanoparticles; fluorescent conjugated; targeted cancer; cancer ... See more keywords
Functionalized Peptide-Based Nanoparticles for Targeted Cancer Nanotherapeutics: A State-of-the-Art Review
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03974
Abstract: Cancer mortality is increasing at an alarming rate across the globe. Albeit, many therapeutics are available commercially, they are not effective and have no cure up to today. Moreover, the knowledge gap in cancer therapy… read more here.
Keywords: targeted cancer; peptide based; review; functionalized peptide ... See more keywords
Reprogramming Synthetic Cells for Targeted Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.1c00631
Abstract: Advances in synthetic biology enable the reprogramming of bacteria as smart agents to specifically target tumors and locally release anticancer drugs in a highly controlled manner. However, the bench-to-bedside translation of engineered bacteria is often… read more here.
Keywords: targeted cancer; biology; simcells mini; cancer therapy ... See more keywords
Aggregation Enhanced Responsiveness of Rationally Designed Probes to Hydrogen Sulfide for Targeted Cancer Imaging.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c06533
Abstract: Activatable molecular probes hold great promise for targeted cancer imaging. However, the hydrophobic nature of most conventional probes makes them generate precipitated agglomerate in aqueous media, thereby annihilating their responsiveness to analytes and precluding their… read more here.
Keywords: aggregation enhanced; designed probes; enhanced responsiveness; targeted cancer ... See more keywords
Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09574
Abstract: Owing to the specific and high binding affinity of aptamers to their targets, aptamer-drug conjugates (ApDCs) have emerged as a promising drug delivery system for targeted cancer therapy. However, in a conventional ApDC, the aptamer… read more here.
Keywords: targeted cancer; nucleoside analogues; cancer therapy; drug ... See more keywords
Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00947-7
Abstract: Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing… read more here.
Keywords: cancer; drug conjugate; drug; antibody drug ... See more keywords
A potent targeted cancer nanotherapeutic
Sign Up to like & getrecommendations! Published in 2019 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-019-0390-7
Abstract: An antibody-modified nanoparticle encapsulating a pH-sensitive taxane prodrug, and targeting an overexpressed receptor in tumours, improves the tolerability and anticancer efficacy of the active drug in multiple animal models. read more here.
Keywords: potent targeted; cancer nanotherapeutic; targeted cancer;