B7-H3-targeted CAR-T cell therapy for solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Reviews of Immunology"
DOI: 10.1080/08830185.2022.2102619
Abstract: Abstract Since B7-H3 is overexpressed or amplified in many types of solid tumors with a restricted expression in the normal tissues, it has been an emerging immunotherapeutic target for solid tumors. This review will focus… read more here.
Keywords: targeted car; therapy; car; solid tumors ... See more keywords
Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aav1648
Abstract: CD19-targeted CAR T cells show sustained CD19+ B cell depletion and profound therapeutic benefit in ameliorating disease in mouse models of lupus. CAR T cells: Not just for cancer CD19-targeted chimeric antigen receptor (CAR) T… read more here.
Keywords: cd19; targeted car; cd19 targeted; car cells ... See more keywords
Safety and efficacy of autologous and allogeneic humanized CD19-targeted CAR-T cell therapy for patients with relapsed/refractory B-ALL
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005701
Abstract: Background Murine chimeric antigen receptor T (CAR-T) cell therapy has demonstrated clinical benefit in patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). However, the potential immunogenicity of the murine single-chain variable fragment domain may… read more here.
Keywords: cell; safety; targeted car; therapy ... See more keywords
Development and Evaluation of a Human Single Chain Variable Fragment (scFv) Derived Bcma Targeted CAR T Cell Vector Leads to a High Objective Response Rate in Patients with Advanced MM
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.742.742
Abstract: Patients with relapsed/refractory MM (RRMM) rarely obtain durable remissions with available therapies. Clinical use of BCMA targeted CAR T cell therapy was first reported in 12/2015 for RRMM, and based on small numbers, preliminary results… read more here.
Keywords: targeted car; car cells; bcma targeted; cell ... See more keywords
Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.958082
Abstract: Background Chimeric antigen receptor T (CAR-T) cell therapy has made significant advances for hematological malignancies but encounters obstacles in the treatment of solid tumors mainly due to tumor immunosuppressive microenvironment. Methods Immunohistochemistry analysis was performed… read more here.
Keywords: targeted car; fap; malignant solid; car ... See more keywords