Hydrophilic Small Molecules That Harness Transthyretin To Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents.
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DOI: 10.1021/acs.molpharmaceut.9b00432
Abstract: The hydrophobicity of many chemotherapeutic agents usually results in their nonselective passive distribution into healthy cells and organs causing collateral toxicity. Ligand-targeted drugs (LTDs) are a promising class of targeted anticancer agents. The hydrophilicity of… read more here.
Keywords: chemotherapeutic agents; targeted chemotherapeutic; circulation half; efficacy ... See more keywords