Targeted deep sequencing of effusion cytology samples is feasible, informs spatiotemporal tumor evolution, and has clinical and diagnostic utility
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1002/gcc.22509
Abstract: During the course of disease, many cancer patients eventually present with metastatic disease including peritoneal or pleural spread. In this context, cytology specimens derived from ascites or pleural effusion may help to differentiate malignant from… read more here.
Keywords: targeted deep; spatiotemporal tumor; tumor evolution; cytology ... See more keywords
Locus-Specific DNA Methylation Analysis by Targeted Deep Bisulfite Sequencing.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7774-1_19
Abstract: DNA methylation, i.e., the methylation of cytosine at carbon atom C5, has an important role in the regulation of gene expression. The methylation status of each cytosine in a specific genomic region can be determined… read more here.
Keywords: methylation; deep bisulfite; targeted deep; bisulfite sequencing ... See more keywords
Targeted deep sequencing helps distinguish independent primary tumors from intrapulmonary metastasis for lung cancer diagnosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03227-5
Abstract: Multiple lung lesions found in a single patient at the time of diagnosis often pose a diagnostic dilemma: are these lesions independent primary tumors (IPT) or the result of intrapulmonary metastases (IPM)? While traditional pathological… read more here.
Keywords: independent primary; diagnosis; targeted deep; metastasis ... See more keywords
Intratumor heterogeneity inferred from targeted deep sequencing as a prognostic indicator
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DOI: 10.1038/s41598-019-41098-0
Abstract: Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations… read more here.
Keywords: index; targeted deep; heterogeneity; cancer ... See more keywords
Characterization of genomic clones by targeted deep sequencing of ctDNA to monitor liver cancer
Sign Up to like & getrecommendations! Published in 2021 at "Translational Cancer Research"
DOI: 10.21037/tcr-21-1005
Abstract: Citation for published version (APA): Sun, Y., Kong, X., Yu, J., Zheng, X., Lin, M., Cheng, Z., Wang, H., An, N., Xie, Y., Zeng, S., Xue, S., Xia, M., Wei, X., Song, L., Liu, F.,… read more here.
Keywords: targeted deep; genomic clones; clones targeted; characterization genomic ... See more keywords