Targeted Deletion of Hsf1, 2, and 4 Genes in Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7477-1_1
Abstract: Heat shock transcription factors (Hsfs) regulate transcription of heat shock proteins as well as other genes whose promoters contain heat shock elements (HSEs). There are at least five Hsfs in mammalian cells, Hsf1, Hsf2, Hsf3,… read more here.
Keywords: deletion hsf1; hsf1 genes; targeted deletion; heat shock ... See more keywords
Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-04081-5
Abstract: Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in intestinal epithelial cells (floxed K8 and Villin-Cre1000 and Villin-CreERt2)… read more here.
Keywords: intestinal epithelial; integrity; epithelial cells; targeted deletion ... See more keywords
Targeted deletion of a 170-kb cluster of LINE-1 repeats and implications for regional control.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.221366.117
Abstract: Approximately half the mammalian genome is composed of repetitive sequences, and accumulating evidence suggests that some may have an impact on genome function. Here, we characterized a large array class of repeats of long-interspersed elements… read more here.
Keywords: line array; array; line; control ... See more keywords
Targeted deletion of GD3 synthase protects against MPTP‐induced neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Genes"
DOI: 10.1111/gbb.12377
Abstract: Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown… read more here.
Keywords: gd3; mice; gd3 synthase; targeted deletion ... See more keywords
Targeted Deletion of Centrin in Leishmania braziliensis Using CRISPR-Cas9-Based Editing
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.790418
Abstract: Leishmania braziliensis is the main causative agent of Tegumentary Leishmaniasis in the Americas. However, difficulties related to genome manipulation, experimental infection, and parasite growth have so far limited studies with this species. CRISPR-Cas9-based technology has… read more here.
Keywords: leishmania; braziliensis; leishmania braziliensis; crispr cas9 ... See more keywords
Targeted Deletion of the Claudin12 Gene in Mice Increases Articular Cartilage and Inhibits Chondrocyte Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.931318
Abstract: To study the role of Claudin (CLDN)12 in bone, we developed mice with a targeted deletion of exon2 in the Cldn12 gene for skeletal phenotype analysis. Micro-CT analysis of the secondary spongiosa of distal femurs… read more here.
Keywords: targeted deletion; gene; articular cartilage; mice ... See more keywords