Targeted Delivery of PD‐L1‐Derived Phosphorylation‐Mimicking Peptides by Engineered Biomimetic Nanovesicles to Enhance Osteosarcoma Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200955
Abstract: Osteosarcoma is a rare malignant bone‐originating tumor that usually occurs in young people. Programmed cell death 1 ligand 1 (PD‐L1), an immune checkpoint protein, is highly expressed in osteosarcoma tissues. Several recent studies have indicated… read more here.
Keywords: derived phosphorylation; npm localized; phosphorylation mimicking; phosphorylation ... See more keywords
A Cyclodiaryliodonium NOX Inhibitor for the Treatment of Pancreatic Cancer Via Enzyme-activatable Targeted Delivery by Sulfated Glycosaminoglycan Derivatives.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203011
Abstract: Pancreatic cancer renders a principal cause of cancer mortalities with a dismal prognosis, lacking sufficiently safe and effective therapeutics. Here, we rationally design diversified cyclodiaryliodonium NADPH oxidase (NOX) inhibitors with tens of nanomolar optimal growth… read more here.
Keywords: pancreatic cancer; glycosaminoglycan derivatives; sulfated glycosaminoglycan; cancer ... See more keywords
Synthesis and in vitro assessment of novel water‐soluble dextran‐docetaxel conjugates as potential pH sensitive system for tumor‐targeted delivery
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.45457
Abstract: Docetaxel is a potent taxane agent mostly used in breast, lung, and prostate cancers. Its low water solubility is the major drawback that leads to use of Tween 80 as surfactant and ethanol as solvent… read more here.
Keywords: water; dextran; solubility; targeted delivery ... See more keywords
Modeling bioaffinity-based targeted delivery of antimicrobials to Escherichia coli biofilms using yeast microparticles. Part II: parameter evaluation and validation.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27969
Abstract: The design of bioaffinity-based targeted delivery systems for biofilm inactivation may require a comprehensive understanding of physicochemical and biochemical properties of biobased antimicrobial particles and their interactions with biofilm. In this study, Escherichia coli biofilm… read more here.
Keywords: inactivation; bioaffinity based; targeted delivery; yeast microparticles ... See more keywords
Self‐Assembled Supramolecular Nanoparticles for Targeted Delivery and Combination Chemotherapy
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800291
Abstract: It is challenging but imperative to merge imaging agents and small molecule therapeutics into one nanoentity for diagnosis and treatment. Herein, we constructed polymeric nanoparticles for targeted delivery and combination chemotherapy, which formed through host–guest… read more here.
Keywords: combination; combination chemotherapy; delivery; self assembled ... See more keywords
Chitosan Nanomedicine in Cancer Therapy: Targeted Delivery and Cellular Uptake.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100005
Abstract: Nanomedicine has gained much attention for the management and treatment of cancers due to the distinctive physicochemical properties of the drug-loaded particles. Chitosan's cationic nature is attractive for the development of such particles for drug… read more here.
Keywords: chitosan particles; delivery; delivery cellular; cellular uptake ... See more keywords
A Poly(Propyleneimine) Dendrimer-Based Polyplex-System for Single-Chain Antibody-Mediated Targeted Delivery and Cellular Uptake of SiRNA.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201700072
Abstract: Therapeutics based on small interfering RNAs (siRNAs) offer a great potential to treat so far incurable diseases or metastatic cancer. However, the broad application of siRNAs using various nonviral carrier systems is hampered by unspecific… read more here.
Keywords: system; delivery; single chain; poly propyleneimine ... See more keywords
Minicell-Based Targeted Delivery of shRNA to Cancer Cells: An Experimental Protocol.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9220-1_9
Abstract: Bacterial minicell has emerged as a novel targeted delivery system for RNAi-based therapeutics. In this chapter, we have described the detailed protocol for the preparation of minicell-based targeted delivery system for shRNA. Initially, minicell-producing parent bacterial… read more here.
Keywords: microscopy; delivery; minicell based; cancer ... See more keywords
A new strategy for targeted delivery of non-water-soluble porphyrins in chitosan-albumin capsules
Sign Up to like & getrecommendations! Published in 2017 at "Colloid and Polymer Science"
DOI: 10.1007/s00396-017-4191-9
Abstract: AbstractThis study was focused on obtaining polymer complex of 5-(4′-N-tert-butyloxycarbonylglicinaminophenyl)-10,15,20-triphenylporphine and 5-(4′-amonophenyl)-10,15,20-triphenylporphine with chitosan. The polymer complexes were characterized spectrally and calorimetrically. The existence of a substituent capable of forming hydrogenic complexes with proteins and… read more here.
Keywords: water; polymer; new strategy; targeted delivery ... See more keywords
Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment
Sign Up to like & getrecommendations! Published in 2021 at "Nano Research"
DOI: 10.1007/s12274-021-3894-x
Abstract: The etiology of chronic kidney disease (CKD) is complex and diverse, which could be briefly categorized to glomerular- or tubular-originated. However, the final outcomes of CKD are mainly glomerular sclerosis, endothelial dysfunction and injury, and… read more here.
Keywords: treatment; kidney disease; targeted delivery;
Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E-/- mice.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119550
Abstract: Unresolved inflammation is a hallmark of many deadly diseases including atherosclerosis, a silent pathological condition behind majority of cardiovascular diseases. Yet, anti-inflammatory drugs are not clinically used in the treatment of patients with atherosclerosis. The… read more here.
Keywords: anti inflammatory; cytokine; inflammation; inflammatory cytokine ... See more keywords