In vivo imaging xenograft models for the evaluation of anti‐brain tumor efficacy of targeted drugs
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DOI: 10.1002/cam4.1255
Abstract: Molecular‐targeted drugs are generally effective against tumors containing driver oncogenes, such as EGFR, ALK, and NTRK1. However, patients harboring these oncogenes frequently experience a progression of brain metastases during treatment. Here, we present an in… read more here.
Keywords: progression; vivo imaging; targeted drugs; brain ... See more keywords
TRPV1-Targeted Drugs in Development for Human Pain Conditions
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DOI: 10.1007/s40265-020-01429-2
Abstract: The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators. TRPV1 is found in… read more here.
Keywords: chronic pain; targeted drugs; trpv1 targeted; development ... See more keywords
Solvent Sites Improve Docking Performance of Protein-Protein Complexes and Protein-Protein Interface-Targeted Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00264
Abstract: Protein-protein interactions (PPIs) are essential, and modulating their function through PPI-targeted drugs is an important research field. PPI sites are shallow protein surfaces readily accessible to the solvent, thus lacking a proper pocket to fit… read more here.
Keywords: targeted drugs; protein protein; ppi; solvent sites ... See more keywords
Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors
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DOI: 10.1038/s41388-019-0965-5
Abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis and minimally responsive to conventional treatment, lending urgency… read more here.
Keywords: drugs mtor; topoisomerase targeted; dna topoisomerase; nerve sheath ... See more keywords
Application of new targeted drugs in relapsed/refractory primary central nervous system lymphoma
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DOI: 10.1080/16078454.2021.2019363
Abstract: ABSTRACT The prognosis of patients with relapsed and refractory primary central nervous system diffuse large B cell lymphoma (PCNSL) is poor and there is no standard salvage treatment currently available. Gene expression profiling and next-generation… read more here.
Keywords: targeted drugs; primary central; relapsed refractory; central nervous ... See more keywords
Chemokine receptor CXCR4: An important player affecting the molecular-targeted drugs commonly used in hematological malignancies
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2020.1839885
Abstract: ABSTRACT Introduction A variety of molecular-targeted drugs have been widely used in hematological malignancies and have shown great advances. Nevertheless, as the use of drugs in clinical practice increases, the problem of relapse or of… read more here.
Keywords: molecular targeted; hematological malignancies; targeted drugs; chemokine receptor ... See more keywords
Incidence of opportunistic infections in patients with rheumatoid arthritis treated with different molecular-targeted drugs: A population-based retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Modern rheumatology"
DOI: 10.1093/mr/roac133
Abstract: OBJECTIVE We compared the incidences of four opportunistic infections (OI) in patients with rheumatoid arthritis (RA) treated with molecular-targeted drugs from big claims data. MATERIALS AND METHODS We identified 205 906 patients with RA who… read more here.
Keywords: targeted drugs; incidence; patients rheumatoid; molecular targeted ... See more keywords
Prognosis of patients with newly diagnosed glioblastoma treated with molecularly targeted drugs combined with radiotherapy vs temozolomide monotherapy
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DOI: 10.1097/md.0000000000017759
Abstract: Abstract Background: Glioblastoma (GB) is one of the most common malignancies with limited standard therapies such as surgery, radiotherapy (RT) plus temozolomide (TMZ). Molecularly targeted drugs have been investigated among various clinical trials and are… read more here.
Keywords: molecularly targeted; glioblastoma; patients newly; targeted drugs ... See more keywords
The pathogenesis and development of targeted drugs in acute T lymphoblastic leukaemia
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DOI: 10.1111/bph.16029
Abstract: Acute lymphoblastic leukaemia (ALL) is mainly classified into acute T‐ and B‐lymphoblastic leukaemia according to the source of its lymphocytes, thymus and bone. Among them, the incidence of adult T‐cell accounts for about 25% of… read more here.
Keywords: targeted drugs; lymphoblastic leukaemia; acute lymphoblastic; signalling pathways ... See more keywords
Novel application of metformin combined with targeted drugs on anticancer treatment
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DOI: 10.1111/cas.13849
Abstract: The success of targeted drug therapies for treating cancer patients has attracted broad attention both in the academic community and social society. However, rapidly developed acquired resistance is becoming a newly recognized major challenge to… read more here.
Keywords: application metformin; metformin combined; cancer; targeted drugs ... See more keywords
The Intervention of Nano-targeted Drugs & Angioplastryin Treatment and Prevention of Vascular Restenosis and its Influence on Monocyte Chemotactic Protein-1 in Lower Extremity Angiopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.3.38
Abstract: It was to make use of the nano-targeted drugs and angioplastry to treat and prevent the vascular restenosis and analyze its influence on monocyte chemotactic protein 1 (MCP-1) of lower extremity angiopathy (LEA) patients since… read more here.
Keywords: targeted drugs; extremity angiopathy; lower extremity; group ... See more keywords