Targeted genome editing for the correction or alleviation of primary Immunodeficiencies.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2021.03.001
Abstract: Primary immunodeficiencies (PID) are a growing list of unique disorders that result in a failure of the innate/adaptive immune systems to fully respond to disease or infection. PIDs are classified into five broad categories; B… read more here.
Keywords: targeted genome; correction alleviation; genome editing; primary immunodeficiencies ... See more keywords
Targeted genome editing in acute lymphoblastic leukemia: a review
Sign Up to like & getrecommendations! Published in 2018 at "BMC Biotechnology"
DOI: 10.1186/s12896-018-0455-9
Abstract: BackgroundGenome editing technologies offers new opportunities for tackling diseases such as acute lymphoblastic leukemia (ALL) that have been beyond the reach of previous therapies.ResultsWe show how the recent availability of genome-editing tools such as CRISPR-Cas9… read more here.
Keywords: editing acute; genome editing; lymphoblastic leukemia; targeted genome ... See more keywords
Targeted genome modifications in cereal crops
Sign Up to like & getrecommendations! Published in 2021 at "Breeding Science"
DOI: 10.1270/jsbbs.21019
Abstract: The recent advent of customizable endonucleases has led to remarkable advances in genetic engineering, as these molecular scissors allow for the targeted introduction of mutations or even precisely predefined genetic modifications into virtually any genomic… read more here.
Keywords: genome modifications; modifications cereal; cereal crops; targeted genome ... See more keywords
Targeted genome editing in vivo corrects a Dmd duplication restoring wild‐type dystrophin expression
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202013228
Abstract: Tandem duplication mutations are increasingly found to be the direct cause of many rare heritable diseases, accounting for up to 10% of cases. Unfortunately, animal models recapitulating such mutations are scarce, limiting our ability to… read more here.
Keywords: genome editing; duplication; targeted genome; tandem duplication ... See more keywords
Targeted Genome Mining Reveals the Psychrophilic Clostridium estertheticum Complex as a Potential Source for Novel Bacteriocins, Including Cesin A and Estercticin A
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.801467
Abstract: Antimicrobial resistance in pathogenic bacteria is considered a major public health issue necessitating the discovery of alternative antimicrobial compounds. In this regard, targeted genome mining in bacteria occupying under-explored ecological niches has the potential to… read more here.
Keywords: genome mining; novel; targeted genome; psychrophilic clostridium ... See more keywords
Halogenase-Targeted Genome Mining Leads to the Discovery of (±) Pestalachlorides A1a, A2a, and Their Atropisomers
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11101304
Abstract: Genome mining has become an important tool for discovering new natural products and identifying the cryptic biosynthesis gene clusters. Here, we utilized the flavin-dependent halogenase GedL as the probe in combination with characteristic halogen isotope… read more here.
Keywords: genome mining; targeted genome; halogenase targeted; pestalachlorides a1a ... See more keywords