The effects of targeted immune-regulatory strategies on tumor-specific T-cell responses in vitro
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DOI: 10.1007/s00262-020-02760-z
Abstract: Immune-related adverse events (IrAEs) are auto-immune reactions associated with immune checkpoint inhibitor-based therapy (ICI). Steroids are currently the first-line option for irAE management; however, recent studies have raised concerns regarding their potential impairment of tumor-specific… read more here.
Keywords: targeted immune; specific cell; cell activation; tumor specific ... See more keywords
Estimating the impact of biosimilar entry on prices and expenditures in rheumatoid arthritis: a case study of targeted immune modulators
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DOI: 10.1080/13696998.2022.2113252
Abstract: Abstract Objective To model changes in prices, utilization, and expenditures of targeted immune modulators (TIMs) for rheumatoid arthritis, accounting for biosimilar entry. Methods Using IQVIA National Sales Perspective data between 2013 and 2019, we examined… read more here.
Keywords: entry; targeted immune; immune modulators; exclusivity milestones ... See more keywords
Abstract 5941: Sequencing of targeted- and immune-therapy: delineating time dependent changes in both melanoma cells and the immune microenvironment
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DOI: 10.1158/1538-7445.am2023-5941
Abstract: Targeted and immune therapies have transformed outcomes for melanoma patients, nevertheless, significant challenges remain to maximize their clinical benefit. BRAF/MEK targeted therapy (TT) is associated with very high initial response rates that are typically short-lived,… read more here.
Keywords: time; time dependent; immune microenvironment; therapy ... See more keywords
Transcriptome and proteome analysis of dogs with precursor targeted immune-mediated anemia treated with splenectomy
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DOI: 10.1371/journal.pone.0285415
Abstract: Precursor-targeted immune-mediated anemia (PIMA) in dogs is characterized by persistent non-regenerative anemia and ineffective erythropoiesis, and it is suspected to be an immune-mediated disease. Most affected dogs respond to immunosuppressive therapies; however, some are resistant.… read more here.
Keywords: precursor targeted; immune mediated; analysis; targeted immune ... See more keywords
Epidermal growth factor receptor-targeted immune magnetic liposomes capture circulating colorectal tumor cells efficiently
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DOI: 10.3748/wjg.v24.i3.351
Abstract: AIM To compare the capacity of newly developed epidermal growth factor receptor (EGFR)-targeted immune magnetic liposomes (EILs) vs epithelial cell adhesion molecule (EpCAM) immunomagnetic beads to capture colorectal circulating tumor cells (CTCs). METHODS EILs were… read more here.
Keywords: targeted immune; immune magnetic; factor receptor; growth factor ... See more keywords