Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2020.04.002
Abstract: Abnormalities in leukocytes' function are associated with many immune related disorders, such as cancer, autoimmunity and susceptibility to infectious diseases. Recent developments in Genome-wide-association-studies give rise to new opportunities for novel therapeutics. RNA-based modalities, that… read more here.
Keywords: targeted lipid; nanoparticles rna; rna therapeutics; rna based ... See more keywords
In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Nano Letters"
DOI: 10.1021/acs.nanolett.3c00304
Abstract: Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies for the treatment of hematological disorders. However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required… read more here.
Keywords: targeted lipid; stem progenitor; hematopoietic stem; stem ... See more keywords
The dawn of a new era of targeted lipid-lowering therapies.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehab841
Abstract: Lipid risk factors for cardiovascular disease depend in part on lifestyle, but optimum control of lipids often demands additional measures. Low-density lipoprotein (LDL) doubtless contributes causally to atherosclerosis. Recent human genetic findings have substantiated a… read more here.
Keywords: dawn new; new era; targeted lipid; lipid lowering ... See more keywords