Antibody-Targeted Liposomes for Enhanced Targeting of the Blood-Brain Barrier.
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DOI: 10.1007/s11095-022-03186-1
Abstract: The blood-brain barrier (BBB) hinders therapeutic delivery to the central nervous system (CNS), thereby impeding the development of therapies for brain injury and disease. Receptor-mediated transcytosis (RMT) systems are a promising way to shuttle a… read more here.
Keywords: targeted liposomes; blood brain; antibody; brain barrier ... See more keywords
Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor
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DOI: 10.1016/j.ajog.2016.08.027
Abstract: Background: The ability to provide safe and effective pharmacotherapy during obstetric complications, such as preterm labor or postpartum hemorrhage, is hampered by the systemic toxicity of therapeutic agents leading to adverse side effects in the… read more here.
Keywords: drug delivery; receptor targeted; targeted liposomes; receptor ... See more keywords
Transferrin targeted liposomal 5‐fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.12.026
Abstract: &NA; The purpose of this study was to prepare transferrin (Tf) targeted liposomal 5‐Fluorouracil (5FU) to improve the safety and efficacy of the drug. Liposomes were prepared using thin layer method. Morphology of liposomes was… read more here.
Keywords: liposomal fluorouracil; apoptosis; targeted liposomal; transferrin targeted ... See more keywords
New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety.
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DOI: 10.1016/j.lfs.2019.04.030
Abstract: We previously showed that folate liposomes of 5FU made from Dipalmitoylphosphatidylcholine (DPPC) induced cell death in HT-29 and HeLa cells more potently than bulk 5FU. Also, a primary 5FU liposomal formulation with phosphatidyl choline (PC)… read more here.
Keywords: delivery; safety; targeted liposomes; cancer cells ... See more keywords
A mechanistic study of the effect of transferrin conjugation on cytotoxicity of targeted liposomes
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DOI: 10.1080/02652048.2018.1547325
Abstract: Abstract This study was performed to prepare 5-fluorouracil (5FU) containing targeted liposomes for the safety and efficacy enhancement. Liposomes were prepared using thin layer method and transferrin (Tf) was employed as the targeting ligand. Morphology… read more here.
Keywords: study; mechanistic study; targeted liposomes; transferrin ... See more keywords
Cyclovirobuxine D Brain-Targeted Liposomes Improve Cerebral Ischemia-Reperfusion Injury via Anti-Oxidant Stress and Activating Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3327
Abstract: One of the main issues faced by nervous system diseases is that drugs are difficult to enter the brain. The previous study suggested that Cyclovirobuxine D (CVBD) encapsulated in Angiopep-conjugated Polysorbate 80-Coated Liposomes showed a… read more here.
Keywords: cell; stress; brain targeted; targeted liposomes ... See more keywords
Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes
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DOI: 10.3390/biomedicines10123139
Abstract: Targeted liposomes triggered by ultrasound are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. In this work, a comprehensive model fitting was performed for… read more here.
Keywords: targeted liposomes; vitro release; release profiles; release ... See more keywords